1. 2016
  2. Published

    Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles

    Peccate, C., Mollard, A., Le Hir, M., Julien, L., McClorey, G., Jarmin, S., Le Heron, A., Dickson, G., Benkhelifa-Ziyyat, S., Piétri-Rouxel, F., Wood, M. J., Voit, T. & Lorain, S. 4 Jul 2016 In : Human Molecular Genetics. p. 1-25 25 p.

    Research output: Contribution to journalArticle

  3. Published

    Intrastriatal delivery of integration-deficient lentiviral vectors in a rat model of Parkinson's disease

    Lu-Nguyen, N., Broadstock, M. & Yáñez-Muñoz, R. J. 18 Jun 2016 In : Methods in Molecular Biology. 1448, p. 175-184 10 p.

    Research output: Contribution to journalArticle

  4. Published

    Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research

    Otto, G., Cocorocchio, M., Munoz, L., Tyson, R., Bretschneider, T. & Williams, R. 7 Jun 2016 Methods in Molecular Biology: Chemotaxis. Springer, p. 123-130

    Research output: Chapter in Book/Report/Conference proceedingChapter

  5. Published

    Non-Catalytic Roles of Presenilin throughout evolution

    Otto, G., Sharma, D. & Williams, R. 7 Jun 2016 In : Journal of Alzheimer's Disease. 52, 4, p. 177-1187 11 p.

    Research output: Contribution to journalScientific review

  6. Published

    The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles

    Frej, A., Clark, J., Le Roy, C., Lilla, S., Thomason, P., Otto, G., Churchill, G., Insall, R., Claus, S., Hawkins, P., Stephens, L. & Williams, R. 1 May 2016 In : Molecular and Cellular Biology. 36, 10, p. 1464-1479 16 p.

    Research output: Contribution to journalArticle

  7. Forthcoming

    Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities: Funding priorities in Alzheimer disease research

    Pistollato, F., Ohayon, E., Lam, A., Langley, G., Novak, T., Pamies, D., Perry, G., Trushina, E., Williams, R., Roher, A., hartung, T., Merkley, R. & Chandrasekera, C. 18 Apr 2016 In : Oncotarget.

    Research output: Contribution to journalScientific review

  8. Published
  9. Published

    Current Progress in Therapeutic Gene Editing for Monogenic Diseases

    Prakash, V., Moore, M. & Yáñez-Muñoz, R. J. Mar 2016 In : Molecular Therapy. 24, 3, p. 465-474 10 p.

    Research output: Contribution to journalArticle

  10. Forthcoming

    FOXF2, a novel risk locus for stroke and small artery disease: a genome-wide association study

    The Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)† & Sharma, P. 26 Feb 2016 In : Lancet Neurology.

    Research output: Contribution to journalArticle

  11. Published

    Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

    Cheng, Y-C. , Sharma, P. & 55 others Keenan, T., Zhao, W., Rasheed, A., Ho, W. K., Malik, R., Felix, J. F., Young, R., Shah, N., Samuel, M., Sheikh, N., Mucksavage, M. L., Shah, O., Li, J., Morley, M., Laser, A., Mallick, N. H., Zaman, K. S., Ishaq, M., Rasheed, S. Z., Memon, F-U-R., Ahmed, F., Hanif, B., Lakhani, M. S., Fahim, M., Ishaq, M., Shardha, N. K., Ahmed, N., Mahmood, K., Iqbal, W., Akhtar, S., Raheel, R., O'Donnell, C. J., Hengstenberg, C., März, W., Kathiresan, S., Samani, N., Goel, A., Hopewell, J. C., Chambers, J., Yang, Q., Rosand, J., Boncoraglio, G. B., Kazmi, S. U., Hakonarson, H., Köttgen, A., Kalogeropoulos, A., Frossard, P., Kamal, A., Dichgans, M., Cappola, T., Reilly, M. P., Danesh, J., Rader, D. J., Voight, B. F. & Saleheen, D. 2 Feb 2016 In : Journal of the American College of Cardiology. 67, 4, p. 407-16 10 p.

    Research output: Contribution to journalArticle

  12. Published

    An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling

    Williams, R. & Bate, C. 1 Feb 2016 In : Neuropharmacology. 101, p. 566–575 20 p.

    Research output: Contribution to journalArticle

  13. Published

    Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

    NINDS Stroke Genetics Network (SiGN) & Sharma, P. 1 Feb 2016 In : Lancet Neurology. 15, 2, p. 174–184 11 p.

    Research output: Contribution to journalArticle

  14. Published

    Quantifying the risk of heart disease following acute ischaemic stroke: a meta-analysis of over 50,000 subjects

    Gunnoo, T., Hasan, N., Saleem Khan, M., Slark, J., Bentley, P. & Sharma, P. 20 Jan 2016 In : BMJ Open.

    Research output: Contribution to journalArticle

  15. E-pub ahead of print

    Antisense targeting of 3'end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for Facioscapulohumeral Dystrophy: a new gene silencing approach

    Marsollier, A-C., Ciszewski, L., Mariot, V., Popplewell, L., Voit, T., Dickson, G. & Dumonceaux, J. 19 Jan 2016 In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  16. E-pub ahead of print

    Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2

    Sharma, P. & 62 others Cheng, Y-C., Stanne, T. M., Giese, A-K., Ho, W. K., Traylor, M., Amouyel, P., Holliday, E. G., Malik, R., Xu, H., Kittner, S. J., Cole, J. W., O’Connell, J. R., Danesh, J., Rasheed, A., Zhao, W., Engelter, S., Grond-Ginsbach, C., Kamatani, Y., Lathrop, M., Leys, D., Thijs, V., Metso, T. M., Tatlisumak, T., Pezzini, A., Parati, E. A., Norrving, B., Bevan, S., Rothwell, P. M., Sudlow, C., Slowik, A., Lindgren, A., Walters, M. R., Jannes, . J., Shen, J., Crosslin, D., Doheny, K., Laurie, C. C., Kanse, S. M., Bis, J. C., Fornage, M., Mosley, T. H., Hopewell, J. C., Strauch, K., Müller-Nurasyid, M., Gieger, C., Waldenberger, M., Peters, A., Meisinger, C., Ikram, M. A., Longstreth, W. T., Meschia, J. F., Seshadri, S., Worrall, B., Jern, C., Levi, C., Dichgans, M., Boncoraglio, G. B., Markus, H. S., Debette, S., Rolfs, A., Saleheen, D. & Mitchell, B. D. 5 Jan 2016 In : Stroke. p. 307-316 10 p.

    Research output: Contribution to journalArticle

  17. Published
  18. 2015
  19. E-pub ahead of print

    Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays

    Cocorocchio, M., Ives, R., Clapham, D., Andrews, P. & Williams, R. 22 Dec 2015 In : ALTEX. 4

    Research output: Contribution to journalArticle

  20. Published

    piggyBac transposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts

    Loperfido, M., Jarmin, S., Dastidar, S., Di Matteo, M., Perini, I., Moore, M., Nair, N., Samara-Kuko, E., Athanasopoulos, T., Tedesco, F. S., Dickson, G., Sampaolesi, M., VandenDriessche, T. & Chuah, M. K. 17 Dec 2015 In : Nucleic Acids Research. p. 1-17 17 p.

    Research output: Contribution to journalArticle

  21. Published

    Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag-pol-nef antigen

    Herath, S., Le Heron, A., Colloca, S., Bergin, P., Patterson, S., Weber, J., Tatoud, R. & Dickson, G. 15 Dec 2015 In : Vaccine. 33, 51, p. 7283–7289 7 p.

    Research output: Contribution to journalArticle

  22. E-pub ahead of print

    Seizure control by decanoic acid through direct AMPA receptor inhibition

    Chang, P-S., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J., Chen, P., Walker, M. & Williams, R. 25 Nov 2015 In : Brain. p. 1-13 13 p.

    Research output: Contribution to journalArticle

  23. Published

    Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells

    Massouridès, E., Polentes, J., Mangeot, P-E., Mournetas, V., Nectoux, J., Deburgrave, N., Nusbaum, P., Leturcq, F., Popplewell, L., Dickson, G., Wein, N., Flanigan, K. M., Peschanski, M., Chelly, J. & Pinset, C. 14 Nov 2015 In : Skeletal Muscle. 5, 40, p. 40

    Research output: Contribution to journalArticle

  24. Published
  25. E-pub ahead of print

    Estimating weight of acute stroke patients when dosing for thrombolysis

    Barrow , T., Khan , M. S., Halse , O., Bentley , P. & Sharma, P. 10 Nov 2015 In : Stroke. p. 228-231 4 p.

    Research output: Contribution to journalArticle

  26. Published

    Adeno-Associated Virus (AAV) Mediated Dystrophin Gene Transfer Studies and Exon Skipping Strategies for Duchenne Muscular Dystrophy (DMD)

    Kawecka, K., Theodoulides, M., Hasoglu, Y., Jarmin, S., Kymalainen, H., Le-Heron, A., Popplewell, L., Malerba, A., Dickson, G. & Athanasopoulos, T. 1 Aug 2015 In : Current Gene Therapy. 15, 4, p. 395-415 21 p.

    Research output: Contribution to journalArticle

  27. Published

    New experimental therapies for status epilepticus in pre-clinical development

    Walker, M. & Williams, R. 1 Aug 2015 In : Epilepsy and Behaviour. 49, p. 290–293 4 p.

    Research output: Contribution to journalScientific review

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