1. 2014
  2. Published

    Transgenic expression of human glial cell line-derived neurotrophic factor (hGDNF) from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease

    Lu-Nguyen, N. B., Broadstock, M., Schliesser, M. G., Bartholomae, C., von Kalle, C., Schmidt, M. & Yáñez-Muñoz, R. J. 18 Mar 2014 In : Human Gene Therapy.

    Research output: Contribution to journalArticle

  3. Published

    Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors (IDLVs)

    Kymalainen, H., Appelt, J-U., Giordano, F. A., Davies, A. F., Ogilvie, C. M., Ahmed, S. G., Laufs, S., Schmidt, M., Bode, J., Yáñez-Muñoz, R. J. & Dickson, G. 2 Feb 2014 In : Human Gene Therapy.

    Research output: Contribution to journalArticle

  4. Published

    New developments in the use of gene therapy to treat Duchenne muscular dystrophy

    Jarmin, S., Kymalainen, H., Popplewell, L. & Dickson, G. Feb 2014 In : Expert Opinion on Biological Therapy. 14, 2, p. 209-30 22 p.

    Research output: Contribution to journalArticle

  5. Published
  6. Published

    Local Overexpression of the Myostatin Propeptide Increases Glucose Transporter Expression and Enhances Skeletal Muscle Glucose Disposal

    Cleasby, M. E., Jarmin, S., Eilers, W., Elashry, M., Andersen, D. K., Dickson, G. & Foster, K. 28 Jan 2014 In : American journal of physiology. Endocrinology and metabolism.

    Research output: Contribution to journalArticle

  7. In preparation

    A new therapeutic mechanism for the MCT ketogenic diet in seizure control through AMPA receptor inhibition

    Chang, P., Augustin, K., Boddum, K., Sun, M., Terschak, J., Hardege, J., Chen, P., Walker, M. & Williams, R. 2014 In : Science translational medicine.

    Research output: Contribution to journalArticle

  8. Published

    A southern blot protocol to detect chimeric nuclease-mediated gene repair

    Rocca, C. J., Abdul-Razak, H. H., Holmes, M. C., Gregory, P. D. & Yáñez-Muñoz, R. J. 2014 In : Methods in Molecular Biology. 1114, p. 325-38 14 p.

    Research output: Contribution to journalArticle

  9. Published
  10. Published
  11. Published

    Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

    Herath, S., Benlahrech, A., Papagatsias, T., Athanasopoulos, T., Bouzeboudjen, Z., Hervouet, C., Klavinskis, L., Meiser, A., Kelleher, P., Dickson, G. & Patterson, S. 2014 In : PLoS One. 9, 2, p. e88327

    Research output: Contribution to journalArticle

  12. Published

    Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

    Bartus, K., James, N. D., Didangelos, A., Bosch, K. D., Verhaagen, J., Yáñez (or Yáñez-Muñoz), R. J., Rogers, J. H., Schneider, B. L., Muir, E. M. & Bradbury, E. J. 2014 In : The Journal of Neuroscience. 34, 14, p. 4822– 4836

    Research output: Contribution to journalArticle

  13. 2013
  14. Published

    Lentiviral Vector-Mediated RNA Silencing in the Central Nervous System

    Hutson, T. H., Foster, E., Moon, L. D. F. & Yáñez-Muñoz, R. J. 1 Nov 2013 In : Human Gene Therapy. Methods.

    Research output: Contribution to journalArticle

  15. Published

    Transgene delivery to endothelial cultures derived from porcine carotid artery ex vivo

    Andoh, J., Sawyer, B., Szewczyk, K., Nortley, M., Rossetti, T., Loftus, I. M., Yáñez-Muñoz, R. J. & Hainsworth, A. H. Oct 2013 In : Translational Stroke Research. 4, 5, p. 507-14 8 p.

    Research output: Contribution to journalArticle

  16. Published

    Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in

    Popplewell, L., Koo, T., Leclerc, X., Duclert, A., Mamchaoui, K., Gouble, A., Mouly, V., Voit, T., Pâques, F., Cédrone, F., Isman, O., Yáñez (or Yáñez-Muñoz), R. J. & Dickson, G. Jul 2013 In : Human Gene Therapy. 24, 7, p. 692-701 10 p.

    Research output: Contribution to journalArticle

  17. Published

    Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord

    Peluffo, H., Foster, E., Ahmed, S. G., Lago, N., Hutson, T. H., Moon, L., Yip, P., Wanisch, K., Caraballo-Miralles, V., Olmos, G., Lladó, J., McMahon, S. B. & Yáñez-Muñoz, R. J. Jun 2013 In : Gene Therapy. 20, p. 645-657

    Research output: Contribution to journalArticle

  18. Published

    Functional characterization of Clostridium difficile spore coat proteins

    Permpoonpattana, P., Phetcharaburanin, J., Mikelsone, A., Dembek, M., Tan, S., Brisson, M-C., La Ragione, R., Brisson, A. R., Fairweather, N., Hong, H. A. & Cutting, S. M. 1 Apr 2013 In : Journal of Bacteriology. 195, 7, p. 1492-1503 12 p.

    Research output: Contribution to journalArticle

  19. Published

    Elevated Transcription of the Gene QSOX1 Encoding Quiescin Q6 Sulfhydryl Oxidase 1 in Breast Cancer

    Soloviev, M., Esteves, M. P., Amiri, F., Crompton, M. R. & Rider, C. 27 Feb 2013 In : PLoS One. 8, 2, e57327

    Research output: Contribution to journalArticle

  20. Published
  21. Published

    Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

    Dickson, J. G. & 50 others Tremblay, J. P., Xiao, X., Aartsma-Rus, A., Barbas, C., Blau, H. M., Bogdanove, A. J., Boycott, K., Braun, S., Breakefield, X. O., Bueren, J. A., Buschmann, M., Byrne, B. J., Calos, M., Cathomen, T., Chamberlain, J., Chuah, M., Cornetta, K., Davies, K. E., Duchateau, P., Flotte, T. R., Gaudet, D., Gersbach, C. A., Gilbert, R., Glorioso, J., Herzog, R. W., High, K. A., Huang, W., Huard, J., Joung, J. K., Liu, D., Liu, D., Lochmüller, H., Lustig, L., Martens, J., Massie, B., Mavilio, F., Mendell, J. R., Nathwani, A., Ponder, K., Porteus, M., Puymirat, J., Samulski, J., Takeda, S., Thrasher, A., VandenDriessche, T., Wei, Y., Wilson, J. M., Wilton, S. D., Wolfe, J. H. & Gao, G. Feb 2013 In : Molecular Therapy. 21, 2, p. 266-8 3 p.

    Research output: Contribution to journalArticle

  22. Published

    Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung

    Yates, L. L., Schnatwinkel, C., Hazelwood, L., Chessum, L., Paudyal, A., Hilton, H., Romero, M. R., Wilde, J., Bogani, D., Sanderson, J., Formstone, C., Murdoch, J. N., Niswander, L. A., Greenfield, A. & Dean, C. H. 15 Jan 2013 In : Developmental Biology. 373, 2, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  23. Published

    A novel human receptor involved in bitter tastant detection identified using the model organism Dictyostelium discoideum

    Robery, S., Tyson, R., Dinh, C., Kuspa, A., Noegel, A., Bretschneider, T., Andrews, P. L. R. & Williams, R. S. B. 2013 In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  24. Published

    Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays

    Bachy, V., Hervouet, C., Becker, P. D., Chorro, L., Carlin, L. M., Herath, S., Papagatsias, T., Barbaroux, J-B., Oh, S-J., Benlahrech, A., Athanasopoulos, T., Dickson, G., Patterson, S., Kwon, S-Y., Geissmann, F. & Klavinskis, L. S. 2013 In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  25. Published

    Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression

    Novorol, C., Burkhardt, J., Wood, K. J., Iqbal, A., Roque, C., Coutts, N., Almeida, A. D., He, J., Wilkinson, C. J. & Harris, W. A. 2013 In : Open biology. 3, 10, p. 130065

    Research output: Contribution to journalArticle

  26. Published

    Mucosal Vaccination against Tuberculosis Using Inert Bioparticles

    Reljic, R., Sibley, L., Huang, J-M., Pepponi, I., Hoppe, A., Huynh, H. & Cutting, S. M. 2013 In : Infection and Immunity. 81, 11, p. 4071-4080

    Research output: Contribution to journalArticle

  27. Forthcoming

    Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner

    Waheed, A., Ludtmann, M., Pakes, N., Robery, S., Kuspa, A., Dinh, C., Baines, D. L., Williams, R. & Carew, M. 2013 In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  28. Published

    Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy

    Raz, V., Sterrenburg, E., Routledge, S., Venema, A., van der Sluijs, B. M., Trollet, C., Dickson, G., van Engelen, B. G. M., van der Maarel, S. M. & Antoniou, M. N. 2013 In : BMC Neurology. 13, p. 70

    Research output: Contribution to journalArticle

  29. Forthcoming

    Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid

    Chang, P., Walker, M. C. & Williams, R. 2013 In : Neurobiology of disease.

    Research output: Contribution to journalArticle

  30. In preparation

    The ketogenic diet-associated fatty acid decanoic acid is a non-competitive antagonist of XXXX YYYYY receptors

    Walker, M., Williams, R., Chang, P., Boddum, K. & Chen, P. 2013 In : Nature Medicine.

    Research output: Contribution to journalArticle

  31. Forthcoming

    The search for better epilepsy treatments: from slime mould to coconuts

    Williams, R. & Walker, M. C. 2013 In : Biochemical Society Transactions. 41

    Research output: Contribution to journalScientific review

  32. Published

    Zizimin and Dock guanine nucleotide exchange factors in cell function and disease

    Pakes, N., Veltman, D. M. & Williams, R. 2013 In : Small GTPases. 4, 1, p. 1-6 6 p.

    Research output: Contribution to journalScientific review

  33. 2012
  34. Published

    Fragmentation of SIV-gag Vaccine Induces Broader T Cell Responses

    Benlahrech, A., Meiser, A., Herath, S., Papagatsias, T., Athanasopoulos, T., Li, F., Self, S., Bachy, V., Hervouet, C., Logan, K., Klavinskis, L., Dickson, G. & Patterson, S. 31 Oct 2012 In : PLoS One. 7, 10, 13 p.ARTN e48038

    Research output: Contribution to journalArticle

  35. Published

    Seizure control by ketogenic diet-associated medium chain fatty acids

    Chang, P., Terbach, N., Plant, N., Chen, P. E., Walker, M. C. & Williams, R. S. B. Jun 2012 In : Neuropharmacology. 69, p. 105-114

    Research output: Contribution to journalArticle

  36. Published

    The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium

    Pakes, N. K., Veltman, D. M., Rivero, F., Nasir, J., Insall, R. & Williams, R. S. B. 15 May 2012 In : Journal of Cell Science. 125, Pt 10, p. 2457-65 9 p.

    Research output: Contribution to journalArticle

  37. Published

    Highly potent delivery method of gp160 envelope vaccine combining lentivirus-like particles and DNA electrotransfer

    Vandermeulen, G., Athanasopoulos, T., Trundley, A., Foster, K., Préat, V., Yáñez-Muñoz, R. J. & Dickson, G. 10 May 2012 In : Journal of Controlled Release. 159, 3, p. 376–383

    Research output: Contribution to journalArticle

  38. Published

    Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

    Elphick, L. M., Pawolleck, N., Guschina, I. A., Chaieb, L., Eikel, D., Nau, H., Harwood, J. L., Plant, N. J. & Williams, R. S. B. Mar 2012 In : Disease Models and Mechanisms. 5, 2, p. 231-240 10 p.

    Research output: Contribution to journalArticle

  39. Published

    Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector

    Hutson, T. H., Verhaagen, J., Yáñez-Muñoz, R. J. & Moon, L. D. F. Jan 2012 In : Gene Therapy. 19, 1, p. 49-60 12 p.

    Research output: Contribution to journalArticle

  40. Published

    AMP-Activated Protein Kinase (AMPK) - Dependent and -Independent Pathways Regulate Hypoxic Inhibition of Transepithelial Na(+) Transport Across Human Airway Epithelial Cells

    Tan, C. D., Smolenski, R. T., Harhun, M. I., Patel, H. K., Ahmed, S. G., Wanisch, K., Yáñez (or Yáñez-Muñoz) , R. J. & Baines, D. L. 2012 In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  41. Published

    Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

    Russell, C. L., Semerdjieva, S., Empson, R. M., Austen, B. M., Beesley, P. W. & Alifragis, P. 2012 In : PLoS One. 7, 8, p. e43201

    Research output: Contribution to journalArticle

  42. Published

    Assembly of protein building blocks using a short synthetic peptide

    Ferrari, E., Soloviev, M., Niranjan, D., Arsenault, J., Gu, C., Vallis, Y., O'Brien, J. & Davletov, B. 2012 In : Bioconjugate Chemistry. 23, 3, p. 479-84 6 p.

    Research output: Contribution to journalArticle

  43. Published

    Brainstem respiratory oscillators develop independently of neuronal migration defects in the Wnt/PCP mouse mutant looptail

    Thoby-Brisson, M., Bouvier, J., Glasco, D. M., Stewart, M. E., Dean, C., Murdoch, J. N., Champagnat, J., Fortin, G. & Chandrasekhar, A. 2012 In : PLoS One. 7, 2, p. e31140

    Research output: Contribution to journalArticle

  44. Published

    Challenges for gene therapy of CNS disorders and implications for Parkinson's disease therapies

    Broadstock, M. & Yáñez (or Yáñez-Muñoz) , R. J. 2012 In : Human Gene Therapy. 23, 4, p. 340-3 4 p.

    Research output: Contribution to journalComment/debate

  45. Published

    Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases

    Yáñez (or Yáñez-Muñoz) , R. J. , Dickson, G. , Popplewell, L. & 28 others Daboussi, F., Zaslavskiy, M., Poirot, L., Loperfido, M., Gouble, A., Guyot, V., Leduc, S., Galetto, R., Grizot, S., Oficjalska, D., Perez, C., Delacôte, F., Dupuy, A., Chion-Sotinel, I., Le Clerre, D., Lebuhotel, C., Danos, O., Lemaire, F., Oussedik, K., Cédrone, F., Epinat, J-C., Smith, J., Koo, T., Vandendriessche, T., Chuah, M. K., Duclert, A., Duchateau, P. & Pâques, F. 2012 In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  46. Published
  47. Published

    Effect of gold nanoparticle conjugation on the activity and stability of functional proteins

    Bailes, J., Gazi, S., Ivanova, R. & Soloviev, M. 2012 In : Methods in Molecular Biology. 906, p. 89-99 11 p.

    Research output: Contribution to journalArticle

  48. Published

    Evaluation of Bacillus subtilis strains as probiotics and their potential as a food ingredient

    Permpoonpattana, P., Hong, H. A., Khaneja, R. & Cutting, S. M. 2012 In : Beneficial microbes. 3, 2, p. 127-35 9 p.

    Research output: Contribution to journalArticle

  49. Published

    Genetic Therapeutic Approaches for Duchenne Muscular Dystrophy

    Foster, H., Popplewell, L. J. & Dickson, G. 2012 In : Human Gene Therapy.

    Research output: Contribution to journalScientific review

  50. Published

    Gold nanoparticle antibody conjugates for use in competitive lateral flow assays

    Bailes, J., Mayoss, S., Teale, P. & Soloviev, M. 2012 In : Methods in Molecular Biology. 906, p. 45-55 11 p.

    Research output: Contribution to journalArticle

  51. Published

    Killed Bacillus subtilis spores as a mucosal adjuvant for an H5N1 vaccine

    Song, M., Hong, H. A., Huang, J-M., Colenutt, C., Khang, D. D., Nguyen, T. V. A., Park, S-M., Shim, B-S., Song, H. H., Cheon, I. S., Jang, J. E., Choi, J., Choi, Y. K., Stadler, K. & Cutting, S. M. 2012 In : Vaccine. 30, 22, p. 3266-77 12 p.

    Research output: Contribution to journalArticle

  52. Published

    Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

    Hutson, T. H., Foster, E., Dawes, J. M., Hindges, R., Yáñez (or Yáñez-Muñoz) , R. J. & Moon, L. D. F. 2012 In : Journal of Gene Medicine. 14, 5, p. 299-315 17 p.

    Research output: Contribution to journalArticle

  53. Published

    Novel cationic carotenoid lipids as delivery vectors of antisense oligonucleotides for exon skipping in duchenne muscular dystrophy

    Popplewell, L. J., Abu-Dayya, A., Khana, T., Flinterman, M., Khalique, N. A., Raju, L., Opstad, C. L., Sliwka, H-R., Partali, V., Dickson, G. & Pungente, M. D. 2012 In : Molecules. 17, 2, p. 1138-48 11 p.

    Research output: Contribution to journalArticle

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