Biomedical Sciences

Functional characterization of Clostridium difficile spore coat proteins

Permpoonpattana, P., Phetcharaburanin, J., Mikelsone, A., Dembek, M., Tan, S., Brisson, M-C., La Ragione, R., Brisson, A. R., Fairweather, N., Hong, H. A. & Cutting, S. M. 1-Apr-2013 In : Journal of Bacteriology. 195, 7, p. 1492-1503, 12 p.

Research output: Contribution to journal › Article

Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors

Semerdjieva, S., Abdul-Razak, H. H., Salim, S. S., Yáñez-Muñoz, R. J., Chen, P. E., Tarabykin, V. & Alifragis, P. Apr-2013 In : Molecular and Cellular Biology. 33, 7, p. 1442-55, 14 p.

Research output: Contribution to journal › Article

Elevated Transcription of the Gene QSOX1 Encoding Quiescin Q6 Sulfhydryl Oxidase 1 in Breast Cancer

Soloviev, M., Esteves, M. P., Amiri, F., Crompton, M. R. & Rider, C. 27-Feb-2013 In : PLoS One.

Research output: Contribution to journal › Article

Activation of EphA receptors mediates the recruitment of the adaptor protein Slap contributing to the downregulation of NMDA receptors.

Semerdjieva, S., Abdul-Razak, H., Syed Salim, S., Yáñez (or Yáñez-Muñoz), R. J., Chen, P., Tarabykin, V. & Alifragis, P. Feb-2013 In : Molecular and Cellular Biology. 33 , 7, p. 1442-1455

Research output: Contribution to journal › Article

A Southern blot protocol to detect chimeric nuclease-mediated gene repair

Rocca, C., Abdul-Razak, H., Holmes, M. C., Gregory, P. D. & Yáñez (or Yáñez-Muñoz), R. J. 2013 In : Methods in Molecular Biology.

Research output: Contribution to journal › Article

Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays

Bachy, V., Hervouet, C., Becker, P. D., Chorro, L., Carlin, L. M., Herath, S., Papagatsias, T., Barbaroux, J-B., Oh, S-J., Benlahrech, A., Athanasopoulos, T., Dickson, G., Patterson, S., Kwon, S-Y., Geissmann, F. & Klavinskis, L. S. 2013 In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal › Article

Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung

Yates, L. L., Schnatwinkel, C., Hazelwood, L., Chessum, L., Paudyal, A., Hilton, H., Romero, M. R., Wilde, J., Bogani, D., Sanderson, J., Formstone, C., Murdoch, J. N., Niswander, L. A., Greenfield, A. & Dean, C. H. 2013 In : Developmental Biology. 373, 2, p. 267-80, 14 p.

Research output: Contribution to journal › Article

Transgene delivery to endothelial cultures derived from porcine carotid artery ex vivo

Andoh, J., Sawyer, B., Szewczyk, K., Nortley, M., Rossetti, T., Loftus, I. M., Yáñez (or Yáñez-Muñoz), R. J. & Hainsworth, A. H. 2013 In : Translational Stroke Research.

Research output: Contribution to journal › Article

Fragmentation of SIV-gag Vaccine Induces Broader T Cell Responses

Benlahrech, A., Meiser, A., Herath, S., Papagatsias, T., Athanasopoulos, T., Li, F., Self, S., Bachy, V., Hervouet, C., Logan, K., Klavinskis, L., Dickson, G. & Patterson, S. 31-Oct-2012 In : PLoS One. 7, 10, 13 p., ARTN e48038

Research output: Contribution to journal › Article

Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord

Peluffo, H., Foster, E., Ahmed, S. G., Lago, N., Hutson, T. H., Moon, L., Yip, P., Wanisch, K., Caraballo-Miralles, V., Olmos, G., Lladó, J., McMahon, S. B. & Yáñez (or Yáñez-Muñoz), R. J. 18-Oct-2012 In : Gene Therapy.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinase (AMPK) - Dependent and -Independent Pathways Regulate Hypoxic Inhibition of Transepithelial Na(+) Transport Across Human Airway Epithelial Cells

Tan, C. D., Smolenski, R. T., Harhun, M. I., Patel, H. K., Ahmed, S. G., Wanisch, K., Yáñez (or Yáñez-Muñoz) , R. J. & Baines, D. L. 2012 In : British Journal of Pharmacology.

Research output: Contribution to journal › Article

Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

Russell, C. L., Semerdjieva, S., Empson, R. M., Austen, B. M., Beesley, P. W. & Alifragis, P. 2012 In : PLoS One. 7, 8, p. e43201

Research output: Contribution to journal › Article

Assembly of protein building blocks using a short synthetic peptide

Ferrari, E., Soloviev, M., Niranjan, D., Arsenault, J., Gu, C., Vallis, Y., O'Brien, J. & Davletov, B. 2012 In : Bioconjugate Chemistry. 23, 3, p. 479-84, 6 p.

Research output: Contribution to journal › Article

Brainstem respiratory oscillators develop independently of neuronal migration defects in the Wnt/PCP mouse mutant looptail

Thoby-Brisson, M., Bouvier, J., Glasco, D. M., Stewart, M. E., Dean, C., Murdoch, J. N., Champagnat, J., Fortin, G. & Chandrasekhar, A. 2012 In : PLoS One. 7, 2, p. e31140

Research output: Contribution to journal › Article

Challenges for gene therapy of CNS disorders and implications for Parkinson's disease therapies

Broadstock, M. & Yáñez (or Yáñez-Muñoz) , R. J. 2012 In : Human Gene Therapy. 23, 4, p. 340-3, 4 p.

Research output: Contribution to journal › Comment/debate

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases

Yáñez (or Yáñez-Muñoz) , R. J. , Dickson, G. , Popplewell, L. & 28 others Daboussi, F., Zaslavskiy, M., Poirot, L., Loperfido, M., Gouble, A., Guyot, V., Leduc, S., Galetto, R., Grizot, S., Oficjalska, D., Perez, C., Delacôte, F., Dupuy, A., Chion-Sotinel, I., Le Clerre, D., Lebuhotel, C., Danos, O., Lemaire, F., Oussedik, K., Cédrone, F., Epinat, J-C., Smith, J., Koo, T., Vandendriessche, T., Chuah, M. K., Duclert, A., Duchateau, P. & Pâques, F. 2012 In : Nucleic Acids Research.

Research output: Contribution to journal › Article

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

Elphick, L. M., Pawolleck, N., Guschina, I. A., Chaieb, L., Eikel, D., Nau, H., Harwood, J. L., Plant, N. J. & Williams, R. S. B. 2012 In : Disease Models and Mechanisms. 5, 2, p. 231-40, 10 p.

Research output: Contribution to journal › Article

Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector

Hutson, T. H., Verhaagen, J., Yáñez (or Yáñez-Muñoz) , R. J. & Moon, L. D. F. 2012 In : Gene Therapy. 19, 1, p. 49-60, 12 p.

Research output: Contribution to journal › Article

Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

Malerba, A., Kang, J. K., McClorey, G., Saleh, A. F., Popplewell, L., Gait, M. J., Wood, M. J. & Dickson, G. 2012 In : Molecular therapy. Nucleic acids. 1, p. e62

Research output: Contribution to journal › Article

Effect of gold nanoparticle conjugation on the activity and stability of functional proteins

Bailes, J., Gazi, S., Ivanova, R. & Soloviev, M. 2012 In : Methods in Molecular Biology. 906, p. 89-99, 11 p.

Research output: Contribution to journal › Article

Evaluation of Bacillus subtilis strains as probiotics and their potential as a food ingredient

Permpoonpattana, P., Hong, H. A., Khaneja, R. & Cutting, S. M. 2012 In : Beneficial microbes. 3, 2, p. 127-35, 9 p.

Research output: Contribution to journal › Article

Genetic Therapeutic Approaches for Duchenne Muscular Dystrophy

Foster, H., Popplewell, L. J. & Dickson, G. 2012 In : Human Gene Therapy.

Research output: Contribution to journal › Scientific review

Gold nanoparticle antibody conjugates for use in competitive lateral flow assays

Bailes, J., Mayoss, S., Teale, P. & Soloviev, M. 2012 In : Methods in Molecular Biology. 906, p. 45-55, 11 p.

Research output: Contribution to journal › Article

Highly potent delivery method of gp160 envelope vaccine combining lentivirus-like particles and DNA electrotransfer

Vandermeulen, G., Athanasopoulos, T., Trundley, A., Foster, K., Préat, V., Yáñez (or Yáñez-Muñoz) , R. J. & Dickson, G. 2012 In : Journal of Controlled Release.

Research output: Contribution to journal › Article

Killed Bacillus subtilis spores as a mucosal adjuvant for an H5N1 vaccine

Song, M., Hong, H. A., Huang, J-M., Colenutt, C., Khang, D. D., Nguyen, T. V. A., Park, S-M., Shim, B-S., Song, H. H., Cheon, I. S., Jang, J. E., Choi, J., Choi, Y. K., Stadler, K. & Cutting, S. M. 2012 In : Vaccine. 30, 22, p. 3266-77, 12 p.

Research output: Contribution to journal › Article

Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

Hutson, T. H., Foster, E., Dawes, J. M., Hindges, R., Yáñez (or Yáñez-Muñoz) , R. J. & Moon, L. D. F. 2012 In : Journal of Gene Medicine. 14, 5, p. 299-315, 17 p.

Research output: Contribution to journal › Article

Novel cationic carotenoid lipids as delivery vectors of antisense oligonucleotides for exon skipping in duchenne muscular dystrophy

Popplewell, L. J., Abu-Dayya, A., Khana, T., Flinterman, M., Khalique, N. A., Raju, L., Opstad, C. L., Sliwka, H-R., Partali, V., Dickson, G. & Pungente, M. D. 2012 In : Molecules. 17, 2, p. 1138-48, 11 p.

Research output: Contribution to journal › Article

Optimizing antisense oligonucleotides using phosphorodiamidate morpholino oligomers

Popplewell, L. J., Malerba, A. & Dickson, G. 2012 In : Methods in Molecular Biology. 867, p. 143-67, 25 p.

Research output: Contribution to journal › Article

Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation

de Klerk, E., Venema, A., Anvar, S. Y., Goeman, J. J., Hu, O., Trollet, C., Dickson, G., den Dunnen, J. T., van der Maarel, S. M., Raz, V. & 't Hoen, P. A. C. 2012 In : Nucleic Acids Research.

Research output: Contribution to journal › Article

Seizure control by ketogenic diet-associated medium chain fatty acids

Chang, P., Terbach, N., Plant, N., Chen, P. E., Walker, M. C. & Williams, R. S. B. 2012 In : NEUROPHARMACOLOGY.

Research output: Contribution to journal › Article

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

Chang, P., Orabi, B., Deranieh, R. M., Dham, M., Hoeller, O., Shimshoni, J. A., Yagen, B., Bialer, M., Greenberg, M. L., Walker, M. C. & Williams, R. S. B. 2012 In : Disease Models and Mechanisms. 5, p. 115-124

Research output: Contribution to journal › Article

The Application of Semiconductor Quantum Dots for Enhancing Peptide Desorption, Improving Peak Resolution and Sensitivity of Detection in Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry

Bailes, J. & Soloviev, M. 2012 In : Methods in Molecular Biology. 906, p. 211-7, 7 p.

Research output: Contribution to journal › Article

The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium

Stowe, T. R., Wilkinson, C. J., Iqbal, A. & Stearns, T. 2012 In : Molecular biology of the cell. 23, 17, p. 3322-35, 14 p.

Research output: Contribution to journal › Article

The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled

Glasco, D. M., Sittaramane, V., Bryant, W., Fritzsch, B., Sawant, A., Paudyal, A., Stewart, M., Andre, P., Cadete Vilhais-Neto, G., Yang, Y., Song, M-R., Murdoch, J. N. & Chandrasekhar, A. 2012 In : Developmental Biology. 369, 2, p. 211-22, 12 p.

Research output: Contribution to journal › Article

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium

Pakes, N. K., Veltman, D. M., Rivero, F., Nasir, J., Insall, R. & Williams, R. S. B. 2012 In : Journal of Cell Science. 125, Pt 10, p. 2457-65, 9 p.

Research output: Contribution to journal › Article

The Use of EST Expression Matrixes for the Quality Control of Gene Expression Data

Milnthorpe, A. T. & Soloviev, M. 2012 In : PLoS One. 7, 3, p. e32966

Research output: Contribution to journal › Article

Zizimin and Dock guanine nucleotide exchange factors in cell function and disease

Pakes, N. K., Veltman, D. M. & Williams, R. 2012 In : Small GTPases. 4, 1

Research output: Contribution to journal › Article

Investigating the Effect of Emetic Compounds on Chemotaxis in Dictyostelium Identifies a Non-Sentient Model for Bitter and Hot Tastant Research

Robery, S., Mukanowa, J., Percie du Sert, N., Andrews, P. L. R. & Williams, R. S. B. 8-Sep-2011 In : PLoS One. 6, 9, p. e24439

Research output: Contribution to journal › Article

Long-term functional adeno-associated virus-microdystrophin expression in the dystrophic CXMDj dog

Koo, T., Okada, T., Athanasopoulos, T., Foster, H., Takeda, S. & Dickson, G. Sep-2011 In : Journal of Gene Medicine. 13, 9, p. 497-506, 10 p.

Research output: Contribution to journal › Article

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Abbs, S., Garralda, M. E., Bourke, J., Wells, D. J., Dickson, G., Wood, M. J. A., Wilton, S. D., Straub, V., Kole, R., Shrewsbury, S. B., Sewry, C., Morgan, J. E., Bushby, K. & Muntoni, F. 13-Aug-2011 In : The Lancet. 378, 9791, p. 595-605, 11 p.

Research output: Contribution to journal › Article

Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment

Pakes, N. K., Jayasinghe, S. N. & Williams, R. S. B. 7-Aug-2011 In : Journal of the Royal Society. Interface. 8, 61, p. 1185-1191, 7 p.

Research output: Contribution to journal › Article

Getting to the Heart of Things in the Field of Cardiovascular Gene Therapy

Dickson, G. Aug-2011 In : Human Gene Therapy. 22, 8, p. 911-912, 2 p.

Research output: Contribution to journal › Editorial

Long-Term Systemic Administration of Unconjugated Morpholino Oligomers for Therapeutic Expression of Dystrophin by Exon Skipping in Skeletal Muscle: Implications for Cardiac Muscle Integrity

Malerba, A., Boldrin, L. & Dickson, G. Aug-2011 In : Nucleic Acid Therapeutics. 21, 4, p. 293-298, 6 p.

Research output: Contribution to journal › Article

Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder

Ludtmann, M. H. R., Boeckeler, K. & Williams, R. S. B. Feb-2011 In : Seminars in Cell and Developmental Biology. 22, 1, p. 105-113, 9 p.

Research output: Contribution to journal › Scientific review

Antisense-induced Myostatin Exon Skipping Leads to Muscle Hypertrophy in Mice Following Octa-guanidine Morpholino Oligomer Treatment

Kang, J. K., Malerba, A., Popplewell, L., Foster, K. & Dickson, G. Jan-2011 In : Molecular Therapy. 19, 1, p. 159-164, 6 p.

Research output: Contribution to journal › Article

Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle

Evans, V. C., Graham, I. R., Athanasopoulos, T., Galley, D. J., Jackson, C. L., Simons, J. P., Dickson, G. & Owen, J. S. 2011 In : Metabolism: clinical and experimental. 60, 4, p. 491-8

Research output: Contribution to journal › Article

Antisense-induced Myostatin Exon Skipping Leads to Muscle Hypertrophy in Mice Following Octa guanidine Morpholino Oligomer Treatment

Kang, J. K., Malerba, A., Popplewell, L., Foster, K. & Dickson, G. 2011 In : Molecular Therapy. 19, 1, p. 159-64

Research output: Contribution to journal › Article

Bacillus probiotics

Cutting, S. M. 2011 In : Food Microbiology. 28, 2, p. 214-20, 7 p.

Research output: Contribution to journal › Article

Bioinformatic and Functional Optimization of Antisense Phosphorodiamidate Morpholino Oligomers (PMOs) for Therapeutic Modulation of RNA Splicing in Muscle

Popplewell, L. J., Graham, I. R., Malerba, A. & Dickson, G. 2011 In : Methods in Molecular Biology. 709, p. 153-78, 26 p.

Research output: Contribution to journal › Article

Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation

Manzo, N., D'Apuzzo, E., Coutinho, P. M., Cutting, S. M., Henrissat, B. & Ricca, E. 2011 In : BMC Microbiology. 11, p. 198

Research output: Contribution to journal › Article

Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer

Mao, X., Boyd, L. K., Yáñez-Muñoz, R. J., Chaplin, T., Xue, L., Lin, D., Shan, L., Berney, D. M., Young, B. D. & Lu, Y. J. 2011 In : American Journal of Cancer Research. 1, p. 604-617

Research output: Contribution to journal › Article

Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice

Malerba, A., Sharp, P. S., Graham, I. R., Arechavala-Gomeza, V., Foster, K., Muntoni, F., Wells, D. J. & Dickson, G. 2011 In : Molecular Therapy. 19, 2, p. 345-54

Research output: Contribution to journal › Article

Codon optimization of the microdystrophin gene for duchene muscular dystrophy gene therapy

Athanasopoulos, T., Foster, H., Foster, K. & Dickson, G. 2011 In : Methods in Molecular Biology. 709, p. 21-37, 17 p.

Research output: Contribution to journal › Article

Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD

Pichavant, C., Aartsma-Rus, A., Clemens, P. R., Davies, K. E., Dickson, G., Takeda, S., Wilton, S. D., Wolff, J. A., Wooddell, C. I., Xiao, X. & Tremblay, J. P. 2011 In : Molecular Therapy. 19, 5, p. 830-40, 11 p.

Research output: Contribution to journal › Scientific review

Delivery of AAV2/9-microdystrophin genes incorporating helix 1 of the coiled-coil motif in the C-terminal domain of dystrophin improves muscle pathology and restores the level of α1-syntrophin and α-dystrobrevin in skeletal muscles of mdx mice

Koo, T., Malerba, A., Athanasopoulos, T., Trollet, C., Boldrin, L., Ferry, A., Popplewell, L. J., Foster, H., Foster, K. & Dickson, G. 2011 In : Human Gene Therapy.

Research output: Contribution to journal › Article

Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients

Anvar, S. Y., 't Hoen, P. A., Venema, A., van der Sluijs, B., van Engelen, B., Snoeck, M., Vissing, J., Trollet, C., Dickson, G., Chartier, A., Simonelig, M., van Ommen, G-J. B., van der Maarel, S. M. & Raz, V. 2011 In : Skeletal Muscle. 1, 1, p. 15

Research output: Contribution to journal › Article

Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms

Milnthorpe, A. T. & Soloviev, M. 2011 In : BMC Bioinformatics. 12, p. 97

Research output: Contribution to journal › Article

Identification and the developmental formation of carotenoid pigments in the yellow/orange Bacillus spore-formers

Perez-Fons, L., Steiger, S., Khaneja, R., Bramley, P. M., Cutting, S. M., Sandmann, G. & Fraser, P. D. 2011 In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids . 1811, 3, p. 177-85, 9 p.

Research output: Contribution to journal › Article

Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium

Terbach, N., Shah, R., Kelemen, R., Klein, P. S., Gordienko, D., Brown, N. A., Wilkinson, C. J. & Williams, R. S. B. 2011 In : Journal of Cell Science. 124, Pt 13, p. 2267-76, 10 p.

Research output: Contribution to journal › Article

Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B

Permpoonpattana, P., Hong, H. A., Phetcharaburanin, J., Huang, J-M., Cook, J., Fairweather, N. F. & Cutting, S. M. 2011 In : Infection and immunity. 79, 6, p. 2295-302, 8 p.

Research output: Contribution to journal › Article

Lentiviral vector integration profiles differ in rodent postmitotic tissues

Bartholomae, C. C., Arens, A., Balaggan, K. S., Yáñez-Muñoz, R. J., Montini, E., Howe, S. J., Paruzynski, A., Korn, B., Appelt, U., MacNeil, A., Cesana, D., Abel, U., Glimm, H., Naldini, L., Ali, R. R., Thrasher, A. J., von Kalle, C. & Schmidt, M. 2011 In : Molecular Therapy. 19, 4, p. 703-710

Research output: Contribution to journal › Article

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

Zhao, R-R., Muir, E. M., Alves, J. N., Rickman, H., Allan, A. Y., Kwok, J. C., Roet, K. C. D., Verhaagen, J., Schneider, B. L., Bensadoun, J-C., Ahmed, S. G., Yáñez (or Yáñez-Muñoz) , R. J., Keynes, R. J., Fawcett, J. W. & Rogers, J. H. 2011 In : Journal of Neuroscience Methods. 201, 1, p. 228-38, 11 p.

Research output: Contribution to journal › Article

Lobe-specific functions of Ca2+·calmodulin in alphaCa2+·calmodulin-dependent protein kinase II activation

Jama, A. M., Gabriel, J., Al-Nagar, A. J., Martin, S., Baig, S. Z., Soleymani, H., Chowdhury, Z., Beesley, P. & Török, K. 2011 In : Journal of Biological Chemistry. 286, 14, p. 12308-16, 9 p.

Research output: Contribution to journal › Article

RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense

Riyahi, T. Y., Frese, F., Steinert, M., Omosigho, N. N., Glöckner, G., Eichinger, L., Orabi, B., Williams, R. S. B. & Noegel, A. A. 2011 In : PLoS One. 6, 11, p. e27311

Research output: Contribution to journal › Article

Surface layers of Clostridium difficile endospores

Permpoonpattana, P., Tolls, E. H., Nadem, R., Tan, S., Brisson, A. & Cutting, S. M. 2011 In : Journal of Bacteriology. 193, 23, p. 6461-70, 10 p.

Research output: Contribution to journal › Article

Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal Myocytes

Gonçalves, M. A., Janssen, J. M., Nguyen, Q. G., Athanasopoulos, T., Hauschka, S. D., Dickson, G. & de Vries, A. A. 2011 In : Molecular Therapy. 19, 7, p. 1331-41

Research output: Contribution to journal › Article

NanoLock polypeptide for the permanent immobilization of recombinant proteins on SNAP25 functionalized supports

Ferrari, E., Darios, F., Soloviev, M. & Davletov, B. 1-Nov-2010 In : European Cells and Materials. 20, SUPPL.3, p. 80, 1 p.

Research output: Contribution to journal › Article

Canine microdystrophin results in remarkable expression and improvement in muscle pathology in a canine model of Duchenne Muscular Dystrophy following AAV gene transfer

Koo, T., Shin, J. H., Athanasopoulos, T., Takashi, O., Foster, H., Shin'ichi, T. & Dickson, G. Oct-2010 In : Human Gene Therapy. 21, 10, p. 1469-1470, 2 p.

Research output: Contribution to journal › Article

Evaluation of the truncated products of exon and multiple exon skipping in DMD therapy

Foster, K., Jarmin, S., Beley, C., Foster, H., Garcia, L. & Dickson, G. Oct-2010 In : Neuromuscular Disorders. 20, 9-10, p. 642, 1 p.

Research output: Contribution to journal › Article

Serum Proteomics in the Diagnosis and Treatment of Haematological Malignancies

Smieszek, S., Bailes, J. & Soloviev, M. Oct-2010 In : Current Proteomics . 7, 3, p. 195-208, 14 p.

Research output: Contribution to journal › Scientific review

Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP

Chang, P., Chandler, K. E., Williams, R. S. B. & Walker, M. C. Aug-2010 In : Epilepsia. 51, 8, p. 1533-1542, 10 p.

Research output: Contribution to journal › Article

Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes

King, J., Keim, M., Teo, R., Weening, K. E., Kapur, M., McQuillan, K., Ryves, J., Rogers, B., Dalton, E., Williams, R. S. B. & Harwood, A. J. 17-Jun-2010 In : PLoS One. 5, 6, 10 p.

Research output: Contribution to journal › Article

Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres

Trollet, C., Anvar, S. Y., Venema, A., Hargreaves, I. P., Foster, K., Vignaud, A., Ferry, A., Negroni, E., Hourde, C., Baraibar, M. A., 't Hoen, P. A. C., Davies, J. E., Rubinsztein, D. C., Heales, S. J., Mouly, V., van der Maarel, S. M., Butler-Browne, G., Raz, V. & Dickson, G. 1-Jun-2010 In : Human Molecular Genetics. 19, 11, p. 2191-2207, 17 p.

Research output: Contribution to journal › Article

Carotenoids found in Bacillus

Khaneja, R., Perez-Fons, L., Fakhry, S., Baccigalupi, L., Steiger, S., To, E., Sandmann, G., Dong, T. C., Ricca, E., Fraser, P. D. & Cutting, S. M. Jun-2010 In : Journal of applied microbiology. 108, 6, p. 1889-1902, 14 p.

Research output: Contribution to journal › Article

A justice system that denies free will is not based on justice

McEvoy, J. P. 18-May-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. E81-E81, 1 p.

Research output: Contribution to journal › Letter

Antisense Oligonucleotide-Induced Multiexon Skipping in Duchenne Muscular Dystrophy

Popplewell, L. J. & Dickson, G. Apr-2010 In : Human Gene Therapy. 21, 4, p. 507-508, 2 p.

Research output: Contribution to journal › Meeting abstract

Reduced expression of the Ca2+transporter protein PMCA2 slows Ca2+dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination

Empson, R. M., Turner, P. R., Nagaraja, R. Y., Beesley, P. W. & Knopfel, T. 15-Mar-2010 In : Journal of Physiology . 588, 6, p. 907-922, 16 p.

Research output: Contribution to journal › Article

Affinity peptidomics: Peptide selection and affinity capture on hydrogels and microarrays

Zhang, F., Dulneva, A., Bailes, J. & Soloviev, M. 2010 In : Methods in Molecular Biology. 615, p. 313-44, 32 p.

Research output: Contribution to journal › Article

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice

Qu, Y., Glasco, D. M., Zhou, L., Sawant, A., Ravni, A., Fritzsch, B., Damrau, C., Murdoch, J. N., Evans, S., Pfaff, S. L., Formstone, C., Goffinet, A. M., Chandrasekhar, A. & Tissir, F. 2010 In : The Journal of Neuroscience. 30, 28, p. 9392-401, 10 p.

Research output: Contribution to journal › Article

Bacterial-type oxygen detoxification and iron-sulfur cluster assembly in amoebal relict mitochondria

Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K. & Tovar, J. 2010 In : Cellular Microbiology. 12, 3, p. 331-42, 12 p.

Research output: Contribution to journal › Article

Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein

Formstone, C. J., Moxon, C., Murdoch, J., Little, P. & Mason, I. 2010 In : Molecular and Cellular Neuroscience. 44, 3, p. 210-22, 13 p.

Research output: Contribution to journal › Article

Binary polypeptide system for permanent and oriented protein immobilization

Ferrari, E., Darios, F., Zhang, F., Niranjan, D., Bailes, J., Soloviev, M. & Davletov, B. 2010 In : Journal of Nanobiotechnology. 8, p. 9

Research output: Contribution to journal › Article

Challenges with advanced therapy medicinal products and how to meet them

Dickson, J. G. & 66 others Schneider, C. K., Salmikangas, P., Jilma, B., Flamion, B., Todorova, L. R., Paphitou, A., Haunerova, I., Maimets, T., Trouvin, J-H., Flory, E., Tsiftsoglou, A., Sarkadi, B., Gudmundsson, K., O'Donovan, M., Migliaccio, G., Ancāns, J., Maciulaitis, R., Robert, J-L., Samuel, A., Ovelgönne, J. H., Hystad, M., Fal, A. M., Lima, B. S., Moraru, A. S., Turcáni, P., Zorec, R., Ruiz, S., Akerblom, L., Narayanan, G., Kent, A., Bignami, F., Niederwieser, D., Figuerola-Santos, M-A., Reischl, I. G., Beuneu, C., Georgiev, R., Vassiliou, M., Pychova, A., Clausen, M., Methuen, T., Lucas, S., Schüssler-Lenz, M., Kokkas, V., Buzás, Z., MacAleenan, N., Galli, M. C., Linē, A., Gulbinovic, J., Berchem, G., Fraczek, M., Menezes-Ferreira, M., Vilceanu, N., Hrubisko, M., Marinko, P., Timón, M., Cheng, W., Crosbie, G. A., Meade, N., di Paola, M. L., VandenDriessche, T., Ljungman, P., D'Apote, L., Oliver-Diaz, O., Büttel, I., Celis, P. & Committee for Advanced Therapies (CAT) 2010 In : Nature Reviews. Drug Discovery. 9, 3, p. 195-201, 7 p.

Research output: Contribution to journal › Article

Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

Popplewell, L. J., Adkin, C., Arechavala-Gomeza, V., Aartsma-Rus, A., de Winter, C. L., Wilton, S. D., Morgan, J. E., Muntoni, F., Graham, I. R. & Dickson, G. 2010 In : Neuromuscular disorders. 20, 2, p. 102-10, 9 p.

Research output: Contribution to journal › Article

Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat

Yip, P. K., Wong, L. F., Sears, T. A., Yáñez-Muñoz, R. J. & McMahon, S. B. 2010 In : PLoS Biology. 8, 6, p. e1000399

Research output: Contribution to journal › Article

Epidermal wound repair is regulated by the planar cell polarity signaling pathway

Caddy, J., Wilanowski, T., Darido, C., Dworkin, S., Ting, S. B., Zhao, Q., Rank, G., Auden, A., Srivastava, S., Papenfuss, T. A., Murdoch, J. N., Humbert, P. O., Boulos, N., Weber, T., Zuo, J., Cunningham, J. M. & Jane, S. M. 2010 In : Developmental Cell. 19, 1, p. 138-47, 10 p.

Research output: Contribution to journal › Article

Labelling of live cells using fluorescent aptamers: binding reversal with DNA nucleases

Terazono, H., Anzai, Y., Soloviev, M. & Yasuda, K. 2010 In : Journal of Nanobiotechnology. 8, p. 8

Research output: Contribution to journal › Article

Mucosal delivery of antigens using adsorption to bacterial spores

Huang, J-M., Hong, H. A., Van Tong, H., Hoang, T. H., Brisson, A. & Cutting, S. M. 2010 In : Vaccine. 28, 4, p. 1021-30, 10 p.

Research output: Contribution to journal › Article

Oral delivery of a DNA vaccine against tuberculosis using operator-repressor titration in a Salmonella enterica vector

Huang, J-M., Sali, M., Leckenby, M. W., Radford, D. S., Huynh, H. A., Delogu, G., Cranenburgh, R. M. & Cutting, S. M. 2010 In : Vaccine. 28, 47, p. 7523-8, 6 p.

Research output: Contribution to journal › Article

Peptidomics: divide et impera

Soloviev, M. 2010 In : Methods in Molecular Biology. 615, p. 3-9, 7 p.

Research output: Contribution to journal › Article

Production of non viral DNA vectors

Schleef, M., Blaesen, M., Schmeer, M., Baier, R., Marie, C., Dickson, G. & Scherman, D. 2010 In : Current Gene Therapy. 10, 6, p. 487-507, 21 p.

Research output: Contribution to journal › Article

Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia

Sugiyama, Y., Stump, R. J. W., Nguyen, A., Wen, L., Chen, Y., Wang, Y., Murdoch, J. N., Lovicu, F. J. & McAvoy, J. W. 2010 In : Developmental Biology. 338, 2, p. 193-201, 9 p.

Research output: Contribution to journal › Article

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin

Darios, F., Niranjan, D., Ferrari, E., Zhang, F., Soloviev, M., Rummel, A., Bigalke, H., Suckling, J., Ushkaryov, Y., Naumenko, N., Shakirzyanova, A., Giniatullin, R., Maywood, E., Hastings, M., Binz, T. & Davletov, B. 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18197-201, 5 p.

Research output: Contribution to journal › Article

The Bone Morphogenetic Protein and Growth Differentiation Cytokine Family, and their Protein Antagonists

Rider, C. C. & Mulloy, B. 2010 In : Biochemical Journal. 429, p. 1-12, 12 p.

Research output: Contribution to journal › Scientific review

The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

Goncalves, M. B., Williams, E. J., Yip, P., Yáñez-Muñoz, R. J., Williams, G. & Doherty, P. 2010 In : British Journal of Pharmacology. 159, 5, p. 1118-25, 8 p.

Research output: Contribution to journal › Article

The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer

Yáñez-Muñoz, R. J. & 23 others Shan, L., Ambroisine, L., Clark, J., Fisher, G., Kudahetti, S. C., Yang, J., Kia, S., Mao, X., Fletcher, A., Flohr, P., Edwards, S., Attard, G., De-Bono, J., Young, B. D., Foster, C. S., Reuter, V., Moller, H., Oliver, T. D., Berney, D. M., Scardino, P., Cuzick, J., Cooper, C. S. & Lu, Y. J. 2010 In : Prostate Cancer and Prostatic Diseases. 13, 2, p. 117-25, 9 p.

Research output: Contribution to journal › Article

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

Paudyal, A., Damrau, C., Patterson, V. L., Ermakov, A., Formstone, C., Lalanne, Z., Wells, S., Lu, X., Norris, D. P., Dean, C. H., Henderson, D. J. & Murdoch, J. N. 2010 In : BMC Developmental Biology. 10, p. 87

Research output: Contribution to journal › Article

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Yates, L. L., Schnatwinkel, C., Murdoch, J. N., Bogani, D., Formstone, C. J., Townsend, S., Greenfield, A., Niswander, L. A. & Dean, C. H. 2010 In : Human Molecular Genetics. 19, 11, p. 2251-67, 17 p.

Research output: Contribution to journal › Article

The relationship between Sonic hedgehog signalling, cilia and neural tube defects.

Murdoch, J. N. & Copp, A. J. 2010 In : Birth Defects Research Part A: Clinical and Molecular Teratology. 88, p. 633-652

Research output: Contribution to journal › Article

Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization

Ghahramani Seno, M. M., Trollet, C., Athanasopoulos, T., Graham, I. R., Hu, P. & Dickson, G. 2010 In : BMC Genomics. 11, p. 345

Research output: Contribution to journal › Article

Using single cell cultivation system for on-chip monitoring of the interdivision timer in Chlamydomonas reinhardtii cell cycle

Matsumura, K., Yagi, T., Hattori, A., Soloviev, M. & Yasuda, K. 2010 In : Journal of Nanobiotechnology. 8, p. 23

Research output: Contribution to journal › Article

Development of thermo-stable Ad-based vaccines expressing ubiquitin fusions of full or fragmented HIV/SIV genetic components

Athanasopoulos, T., Papagatsias, T., Meiser, A., Harris, J., Bachy, V., Benlahrech, A., Herath, S., Roesen, N., Oh, S., Li, F., Self, S., Kwon, S-Y., Fischer, K., Seymour, L., Daniels, R., Almond, N., Klavinskis, L., Logan, K., Patterson, S. & Dickson, G. Nov-2009 In : Human Gene Therapy. 20, 11, p. 1392-1393, 2 p.

Research output: Contribution to journal › Article

PtdIns(3,4,5)P-3 and inositol depletion as a cellular target of mood stabilizers

Teo, R., King, J., Dalton, E., Ryves, J., Williams, R. S. B. & Harwood, A. J. Oct-2009 In : Biochemical Society Transactions. 37, p. 1110-1114, 5 p.

Research output: Contribution to journal › Article

Structure-function studies for the panacea, valproic acid

Terbach, N. & Williams, R. S. B. Oct-2009 In : Biochemical Society Transactions. 37, p. 1126-1132, 7 p.

Research output: Contribution to journal › Article

MOLECULAR INTERACTIONS OF THE PLASMA MEMBRANE CALCIUM ATPase 2 AT PRE- AND POST-SYNAPTIC SITES IN RAT CEREBELLUM

Garside, M. L., Turner, P. R., Austen, B., Strehler, E. E., Beesley, P. W. & Empson, R. M. 18-Aug-2009 In : Neuroscience. 162, 2, p. 383-395, 13 p.

Research output: Contribution to journal › Article

Gene therapy for muscular dystrophy: current progress and future prospects

Trollet, C., Athanasopoulos, T., Popplewell, L., Malerba, A. & Dickson, G. Jul-2009 In : Expert Opinion on Biological Therapy. 9, 7, p. 849-866, 18 p.

Research output: Contribution to journal › Scientific review

Oral vaccine delivery by recombinant spore probiotics

Cutting, S. M., Hong, H. A., Baccigalupi, L. & Ricca, E. 1-Jan-2009 In : International Reviews of Immunology. 28, 6, p. 487-505, 19 p.

Research output: Contribution to journal › Article

Adeno-associated virus-8-mediated intravenous transfer of myostatin propeptide leads to systemic functional improvements of slow but not fast muscle

Foster, K., Graham, I. R., Otto, A., Foster, H., Trollet, C., Yaworsky, P. J., Walsh, F. S., Bickham, D., Curtin, N. A., Kawar, S. L., Patel, K. & Dickson, G. 2009 In : Rejuvenation Research. 12, 2, p. 85-94, 10 p.

Research output: Contribution to journal › Article

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

Benlahrech, A., Harris, J., Meiser, A., Papagatsias, T., Hornig, J., Hayes, P., Lieber, A., Athanasopoulos, T., Bachy, V., Csomor, E., Daniels, R., Fisher, K., Gotch, F., Seymour, L., Logan, K., Barbagallo, R., Klavinskis, L., Dickson, G. & Patterson, S. 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19940-5, 6 p.

Research output: Contribution to journal › Article

Bacillus subtilis isolated from the human gastrointestinal tract

Huynh, H., Khaneja, R., Tam, N. M. K., Cazzato, A., Tan, S., Urdaci, M., Brisson, A., Gasbarrini, A., Barnes, I. & Cutting, S. M. 2009 In : Research in Microbiology. 160, 2, p. 134-143, 10 p.

Research output: Contribution to journal › Article

Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus

Chen, P. E., Errington, M. L., Kneussel, M., Chen, G., Annala, A. J., Rudhard, Y. H., Rast, G. F., Specht, C. G., Tigaret, C. M., Nassar, M. A., Morris, R. G., Bliss, T. V. & Schoepfer, R. 2009 In : Learning and Memory. 16, 10, p. 635-44, 10 p.

Research output: Contribution to journal › Article

Bipolar disorder: molecular and cellular biology

Williams, R. 2009 In : Biochemist. October, p. 54-55

Research output: Contribution to journal › Article

Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos

Wilkinson, C. J., Carl, M. & Harris, W. A. 2009 In : BMC Cell Biology. 10, p. 17, 1 p.

Research output: Contribution to journal › Article

Comprehensive genomic access to vector integration in clinical gene therapy

Yáñez-Muñoz, R. J. & 30 others Gabriel, R., Eckenberg, R., Paruzynski, A., Bartholomae, C. C., Nowrouzi, A., Arens, A., Howe, S. J., Recchia, A., Cattoglio, C., Wang, W., Faber, K., Schwarzwaelder, K., Kirsten, R., Deichmann, A., Ball, C. R., Balaggan, K. S., Ali, R. R., Gaspar, H. B., Biasco, L., Aiuti, A., Cesana, D., Montini, E., Naldini, L., Cohen-Haguenauer, O., Mavilio, F., Thrasher, A. J., Glimm, H., von Kalle, C., Saurin, W. & Schmidt, M. 2009 In : Nature Medicine. 15, 12, p. 1431-6, 6 p.

Research output: Contribution to journal › Article

Defining the natural habitat of Bacillus spore-formers

Huynh, H., To, E., Fakhry, S., Baccigalupi, L., Ricca, E. & Cutting, S. M. 2009 In : Research in Microbiology. 160, 6, p. 375-9, 5 p.

Research output: Contribution to journal › Article

Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene

Popplewell, L. J., Trollet, C., Dickson, G. & Graham, I. R. 2009 In : Molecular Therapy. 17, 3, p. 554-61, 8 p.

Research output: Contribution to journal › Article

Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice

Malerba, A., Thorogood, F. C., Dickson, G. & Graham, I. R. 2009 In : Human Gene Therapy. 20, 9, p. 955-65, 11 p.

Research output: Contribution to journal › Article

Efficient liver-directed gene transfer by in situ generation of retroviral vector from adenoviral templates

Harris, J. D., Roberts, M. L., Perumal, D., Graham, I. R., Patterson, S. & Dickson, G. 2009 In : In Vivo. 23, 6, p. 885-93, 9 p.

Research output: Contribution to journal › Article

Employing multiple models, methods and mechanisms in bipolar disorder research

Williams, R. S. B. 2009 In : Biochemical Society Transactions. 37, Pt 5, p. 1077-9, 3 p.

Research output: Contribution to journal › Article

Evidence for a homodimeric structure of human monocarboxylate transporter 8

Visser, W. E., Philp, N. J., van Dijk, T. B., Klootwijk, W., Friesema, E. C. H., Jansen, J., Beesley, P., Ianculescu, A. G. & Visser, T. J. 2009 In : Endocrinology. 150, 11, p. 5163-70, 8 p.

Research output: Contribution to journal › Article

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit

Otton, H. J., Janssen, A., O'Leary, T., Chen, P. E. & Wyllie, D. J. 2009 In : European Journal of Pharmacology. 614, 1-3, p. 14-21, 8 p.

Research output: Contribution to journal › Article

Integration-deficient Lentiviral Vectors: A Slow Coming of Age

Wanisch, K. & Yáñez-Muñoz, R. J. 2009 In : Molecular Therapy. 17, 8, p. 1316-1332

Research output: Contribution to journal › Scientific review

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

Popplewell, L. , Dickson, G. & 23 others Kinali, M., Arechavala-Gomeza, V., Feng, L., Cirak, S., Hunt, D., Adkin, C., Guglieri, M., Ashton, E., Abbs, S., Nihoyannopoulos, P., Garralda, M. E., Rutherford, M., McCulley, C., Graham, I. R., Wood, M. J. A., Wells, D. J., Wilton, S. D., Kole, R., Straub, V., Bushby, K., Sewry, C., Morgan, J. E. & Muntoni, F. 2009 In : Lancet Neurology. 8, 10, p. 918-28, 11 p.

Research output: Contribution to journal › Article

Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice

Foster, K., Matsakas, A., Otto, A., Macharia, R., Elashry, M. I., Feist, S., Graham, I., Foster, H., Yaworsky, P., Walsh, F., Dickson, G. & Patel, K. 2009 In : Neuromuscular disorders. 19, 7, p. 489-99, 11 p.

Research output: Contribution to journal › Article

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

Patterson, V. L., Damrau, C., Paudyal, A., Reeve, B., Grimes, D. T., Stewart, M. E., Williams, D. J., Siggers, P., Greenfield, A. & Murdoch, J. N. 2009 In : Human Molecular Genetics. 18, 10, p. 1719-39, 21 p.

Research output: Contribution to journal › Article

N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody

Connell, E., Darios, F., Peak-Chew, S., Soloviev, M. & Davletov, B. 2009 In : Biochemistry. 48, 40, p. 9582-9, 8 p.

Research output: Contribution to journal › Article

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

Puddifoot, C. A., Chen, P. E., Schoepfer, R. & Wyllie, D. J. 2009 In : British Journal of Pharmacology. 156, 3, p. 509-18, 10 p.

Research output: Contribution to journal › Article

Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice

Osman, E., Evans, V., Graham, I. R., Athanasopoulos, T., McIntosh, J., Nathwani, A. C., Simons, J. P., Dickson, G. & Owen, J. S. 2009 In : Atherosclerosis. 204, 1, p. 121-6, 6 p.

Research output: Contribution to journal › Article

Quantum dots improve peptide detection in MALDI MS in a size dependent manner

Bailes, J., Vidal, L., Ivanov, D. A. & Soloviev, M. 2009 In : Journal of Nanobiotechnology. 7, p. 10

Research output: Contribution to journal › Article

Searching for protein-protein interactions within the Bacillus subtilis spore coat

Krajcíková, D., Lukácová, M., Müllerová, D., Cutting, S. M. & Barák, I. 2009 In : Journal of Bacteriology. 191, 10, p. 3212-9, 8 p.

Research output: Contribution to journal › Article

The effect of anti-spore antibody responses on the use of spores for vaccine delivery

Yu, L. H. & Cutting, S. M. 2009 In : Vaccine. 27, 34, p. 4576-84, 9 p.

Research output: Contribution to journal › Article

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells

King, J. S., Teo, R., Ryves, J., Reddy, J. V., Peters, O., Orabi, B., Hoeller, O., Williams, R. S. B. & Harwood, A. J. 2009 In : Disease Models and Mechanisms. 2, 5-6, p. 306-312, 7 p.

Research output: Contribution to journal › Article

Redox Reactions of the Non-Heme Iron in Photosystem II: An EPR Spectroscopic Study

McEvoy, J. & Brudvig, G. W. 16-Dec-2008 In : Biochemistry. 47, 50, p. 13394-13403, 10 p.

Research output: Contribution to journal › Article

Exploiting CD34+myoblast quiescence for the establishment of minicircles and S/MAR-containing episomes in the place of antibiotic selective pressure

Fakhro, S., Low, H. S., Foster, K., Beauchamp, J. & Dickson, G. Oct-2008 In : Human Gene Therapy. 19, p. 1114-1114, 1 p.

Research output: Contribution to journal › Meeting abstract

The safety of Bacillus subtilis and Bacillus indicus as food probiotics

Hong, H. A., Huang, J. -M., Khaneja, R., Hiep, L. V., Urdaci, M. C. & Cutting, S. M. Aug-2008 In : Journal of applied microbiology. 105, 2, p. 510-520, 11 p.

Research output: Contribution to journal › Article

Computational insights into the O-2-evolving complex of photosystem II

Sproviero, E. M., McEvoy, J. P., Gascon, J. A., Brudvig, G. W. & Batista, V. S. Jul-2008 In : Photosynthesis Research. 97, 1, p. 91-114, 24 p.

Research output: Contribution to journal › Scientific review

A model of the oxygen-evolving center of photosystem II predicted by structural refinement based on EXAFS Simulations

Sproviero, E. M., Gascon, J. A., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. 28-May-2008 In : Journal of the American Chemical Society. 130, 21, p. 6728-+, 4 p.

Research output: Contribution to journal › Article

QM/MM computational studies of substrate water binding to the oxygen-evolving centre of photosystem II

Sproviero, E. M., Shinopoulos, K., Gascon, J. A., McEvoy, J., Brudvig, G. W. & Batista, V. S. 27-Mar-2008 In : Philosophical Transactions of the Royal Society of London B: Biological Sciences. 363, 1494, p. 1149-1156, 8 p.

Research output: Contribution to journal › Article

Quantum mechanics/molecular mechanics study of the catalytic cycle of water splitting in photosystem II

Sproviero, E. M., Gascon, J. A., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. 19-Mar-2008 In : Journal of the American Chemical Society. 130, 11, p. 3428-3442, 15 p.

Research output: Contribution to journal › Scientific review

Computational studies of the O-2-evolving complex of photosystem II and biomimetic oxomanganese complexes

Sproviero, E. M., Gascon, J. A., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. Feb-2008 In : Coordination Chemistry Reviews. 252, 3-4, p. 395-415, 21 p.

Research output: Contribution to journal › Scientific review

Coelomic expression of a novel bone morphogenetic protein in regenerating arms of the brittle star Amphiura filiformis

Bannister, R., McGonnell, I. M., Graham, A., Thorndyke, M. C. & Beesley, P. W. Jan-2008 In : Development Genes and Evolution. 218, 1, p. 33-38, 6 p.

Research output: Contribution to journal › Article

A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner

Goncalves, M. B., Suetterlin, P., Yip, P., Molina-Holgado, F., Walker, D. J., Oudin, M. J., Zentar, M. P., Pollard, S., Yáñez-Muñoz, R. J., Williams, G., Walsh, F. S., Pangalos, M. N. & Doherty, P. 2008 In : Molecular and Cellular Neuroscience. 38, 4, p. 526-36, 11 p.

Research output: Contribution to journal › Article

Activity of different vaccine-associated promoter elements in human dendritic cells

Papagatsias, T., Rozis, G., Athanasopoulos, T., Gotch, F., Dickson, G. & Patterson, S. 2008 In : Immunology Letters. 115, 2, p. 117-25, 9 p.

Research output: Contribution to journal › Article

Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration

Isman, O., Roberts, M. L., Morgan, J. E., Graham, I. R., Goldring, K., Lawrence-Watt, D. J., Lu, Q. L., Dunckley, M. G., Porter, A. C. G., Partridge, T. A. & Dickson, G. 2008 In : Human Gene Therapy. 19, 10, p. 1000-8, 9 p.

Research output: Contribution to journal › Article

Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer

Foster, H., Sharp, P. S., Athanasopoulos, T., Trollet, C., Graham, I. R., Foster, K., Wells, D. J. & Dickson, G. 2008 In : Molecular Therapy. 16, 11, p. 1825-32, 8 p.

Research output: Contribution to journal › Article

Comprehensive gene expression atlas for the Arabidopsis MAP kinase signalling pathways

Menges, M., Doczi, R., Okresz, L., Morandini, P., Mizzi, L., Soloviev, M., Murray, J. A. H. & Bogre, L. 2008 In : New Phytologist. 179, 3, p. 643-662, 20 p.

Research output: Contribution to journal › Article

Cytoplasmic delivery of antigens, by Bacillus subtilis enhances Th1 responses

Huang, J-M., La Ragione, R. M., Cooley, W. A., Todryk, S. & Cutting, S. M. 2008 In : Vaccine. 26, 48, p. 6043-52, 10 p.

Research output: Contribution to journal › Article

Entamoeba histolytica mitosomes: organelles in search of a function

Aguilera, P., Barry, T. & Tovar, J. 2008 In : Experimental Parasitology. 118, 1, p. 10-6, 7 p.

Research output: Contribution to journal › Scientific review

Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase

Moldt, B., Staunstrup, N. H., Jakobsen, M., Yáñez-Muñoz, R. J. & Mikkelsen, J. G. 2008 In : BMC Biotechnology. 8, p. 60, 10 p.

Research output: Contribution to journal › Article

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7)

Evans, V., Foster, H., Graham, I. R., Foster, K., Athanasopoulos, T., Simons, J. P., Dickson, G. & Owen, J. S. 2008 In : Human Gene Therapy. 19, 6, p. 569-78, 10 p.

Research output: Contribution to journal › Article

Immunostimulatory activity of Bacillus spores

Huang, J-M., La Ragione, R. M., Nunez, A. & Cutting, S. M. 2008 In : FEMS Immunology and Medical Microbiology . 53, 2, p. 195-203, 9 p.

Research output: Contribution to journal › Article

Impaired telomerase activity in human cells expressing GFP-Ku86 fusion proteins

Badie, C., Yáñez-Muñoz, R. J., Muller, C., Salles, B. & Porter, A. C. 2008 In : Cytogenetic and Genome Research. 122, 3-4, p. 326-35, 10 p.

Research output: Contribution to journal › Article

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Wrighton, D. C., Baker, E. J., Chen, P. E. & Wyllie, D. J. 2008 In : Journal of Physiology. 586, 1, p. 211-25, 15 p.

Research output: Contribution to journal › Article

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Chen, P. E., Geballe, M. T., Katz, E., Erreger, K., Livesey, M. R., O'Toole, K. K., Le, P., Lee, C. J., Snyder, J. P., Traynelis, S. F. & Wyllie, D. J. 2008 In : Journal of Physiology. 586, 1, p. 227-45, 19 p.

Research output: Contribution to journal › Article

Non-cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation

Phillips, H. M., Hildreth, V., Peat, J. D., Murdoch, J. N., Kobayashi, K., Chaudhry, B. & Henderson, D. J. 2008 In : Circulation Research. 102, 5, p. 615-623, 9 p.

Research output: Contribution to journal › Article

Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis

Hoang, T. H., Hong, H. A., Clark, G. C., Titball, R. W. & Cutting, S. M. 2008 In : Infection and immunity. 76, 11, p. 5257-65, 9 p.

Research output: Contribution to journal › Article

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology

Ghahramani Seno, M. M., Graham, I. R., Athanasopoulos, T., Trollet, C., Pohlschmidt, M., Crompton, M. R. & Dickson, G. 2008 In : Human Molecular Genetics. 17, 17, p. 2622-32, 11 p.

Research output: Contribution to journal › Article

The impact of the absence of aliphatic glucosinolates on insect herbivory in Arabidopsis

Beekwilder, J., van Leeuwen, W., van Dam, N. M., Bertossi, M., Grandi, V., Mizzi, L., Soloviev, M., Szabados, L., Molthoff, J. W., Schipper, B., Verbocht, H., de Vos, R. C. H., Morandini, P., Aarts, M. G. M. & Bovy, A. 2008 In : PLoS One. 3, 4, p. e2068

Research output: Contribution to journal › Article

The safety of two Bacillus probiotic strains for human use

Sorokulova, I. B., Pinchuk, I. V., Denayrolles, M., Osipova, I. G., Huang, J. M., Cutting, S. M. & Urdaci, M. C. 2008 In : Digestive Diseases and Sciences. 53, 4, p. 954-63, 10 p.

Research output: Contribution to journal › Article

Comparative analysis of antisense oligonucleotide sequences for targeted skipping of Exon 51 during dystrophin Pre-mRNA splicing in human muscle

Arechavala-Gomeza, V., Graham, I. R., Popplewell, L. J., Adams, A. M., Aartsma-Rus, A., Kinali, M., Morgan, J. E., Van Deutekom, J. C., Wilton, S. D., Dickson, G. & Muntoni, F. Sep-2007 In : Human Gene Therapy. 18, 9, p. 798-810, 13 p.

Research output: Contribution to journal › Article

Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid

Xu, X., Mueller-Taubenberger, A., Adley, K. E., Pawolleck, N., Lee, V. W. Y., Wiedemann, C., Sihra, T. S., Maniak, M., Jin, T. & Williams, R. S. B. Jun-2007 In : EUKARYOTIC CELL. 6, 6, p. 899-906, 8 p.

Research output: Contribution to journal › Article

Quantum mechanics/molecular mechanics structural models of the oxygen-evolving complex of photosystem II

Sproviero, E. M., Gascon, J. A., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. Apr-2007 In : Current opinion in structural biology. 17, 2, p. 173-180, 8 p.

Research output: Contribution to journal › Article

The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior

Shimshoni, J. A., Dalton, E. C., Jenkins, A., Eyal, S., Ewan, K., Williams, R. S. B., Pessah, N., Yagen, B., Harwood, A. J. & Bialer, M. Mar-2007 In : Molecular Pharmacology. 71, 3, p. 884-892, 9 p.

Research output: Contribution to journal › Article

A mitosome purification protocol based on percoll density gradients and its use in validating the mitosomal nature of Entamoeba histolytica mitochondrial Hsp70

Tovar, J., Cox, S. S. E. & van der Giezen, M. 2007 In : Methods in Molecular Biology. 390, p. 167-77, 11 p.

Research output: Contribution to journal › Article

APOE epsilon3 gene transfer attenuates brain damage after experimental stroke

McColl, B. W., McGregor, A. L., Wong, A., Harris, J. D., Amalfitano, A., Magnoni, S., Baker, A. H., Dickson, G. & Horsburgh, K. 2007 In : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 27, 3, p. 477-87, 11 p.

Research output: Contribution to journal › Article

Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene

Wishart, T. M., Macdonald, S. H., Chen, P. E., Shipston, M. J., Coleman, M. P., Gillingwater, T. H. & Ribchester, R. R. 2007 In : Molecular Neurodegeneration. 2, p. 21, 1 p.

Research output: Contribution to journal › Article

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization

Phillips, H. M., Rhee, H. J., Murdoch, J. N., Hildreth, V., Peat, J. D., Anderson, R. H., Copp, A. J., Chaudhry, B. & Henderson, D. J. 2007 In : Circulation Research. 101, 2, p. 137-145, 9 p.

Research output: Contribution to journal › Article

Identification of a recurrent t(4;6) chromosomal translocation in prostate cancer

Lane, T. M., Strefford, J. C., Yáñez-Muñoz, R. J., Purkis, P., Forsythe, E., Nia, T., Hines, J., Lu, Y. J. & Oliver, R. T. 2007 In : Journal of Urology. 177, 5, p. 1907-12, 6 p.

Research output: Contribution to journal › Article

Nanobiotechnology today: focus on nanoparticles

Soloviev, M. 2007 In : Journal of Nanobiotechnology. 5, p. 11

Research output: Contribution to journal › Article

Rapid high-resolution karyotyping with precise identification of chromosome breakpoints

Mao, X., James, S. Y., Yáñez-Muñoz, R. J., Chaplin, T., Molloy, G., Oliver, R. T., Young, B. D. & Lu, Y. J. 2007 In : Genes Chromosomes Cancer. 46, 7, p. 675-83, 9 p.

Research output: Contribution to journal › Article

Selection strategy and the design of hybrid oligonucleotide primers for RACE-PCR: cloning a family of toxin-like sequences from Agelena orientalis

Pan, Z., Barry, R., Lipkin, A. & Soloviev, M. 2007 In : BMC Molecular Biology. 8, p. 32

Research output: Contribution to journal › Article

Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence

Golding, J. P., Calderbank, E., Partridge, T. A. & Beauchamp, J. R. 2007 In : Experimental cell research. 313, 2, p. 341-56, 16 p.

Research output: Contribution to journal › Article

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

Erreger, K., Geballe, M. T., Kristensen, A., Chen, P. E., Hansen, K. B., Lee, C. J., Yuan, H., Le, P., Lyuboslavsky, P. N., Micale, N., Jorgensen, L., Clausen, R. P., Wyllie, D. J., Snyder, J. P. & Traynelis, S. F. 2007 In : Molecular Pharmacology. 72, 4, p. 907-20, 14 p.

Research output: Contribution to journal › Article

Taking the time to study competitive antagonism

Wyllie, D. J. & Chen, P. E. 2007 In : British Journal of Pharmacology. 150, 5, p. 541-51, 11 p.

Research output: Contribution to journal › Article

The Binding of Human Betacellulin to Heparin, Heparan Sulfate and Related Polysaccharides

Mummery, R. S., Mulloy, B. & Rider, C. C. 2007 In : Glycobiology. 17, p. 1094-1103, 10 p.

Research output: Contribution to journal › Article

The Major Determinant of the Heparin Binding of Glial Cell-Line Derived Neurotrophic Factor is near the Aminoterminus and is Dispensable for Receptor Binding

Alfano, I., Vora, P., Mummery, R. S., Mulloy, B. & Rider, C. C. 2007 In : Biochemical Journal. 404, p. 131-140, 10 p.

Research output: Contribution to journal › Article

Water-splitting chemistry of photosystem II

McEvoy, J. P. & Brudvig, G. W. Nov-2006 In : Chemical reviews. 106, 11, p. 4455-4483, 29 p.

Research output: Contribution to journal › Scientific review

The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum

Boeckeler, K., Adley, K., Xu, E. X., Jenkins, A., Jin, T. & Williams, R. S. B. Sep-2006 In : EUROPEAN JOURNAL OF CELL BIOLOGY. 85, 9-10, p. 1047-1057, 11 p.

Research output: Contribution to journal › Article

Towards a molecular understanding of human diseases using Dictyostelium discoideum

Williams, R. S. B., Boeckeler, K., Graef, R., Mueller-Taubenberger, A., Li, Z., Isberg, R. R., Wessels, D., Soll, D. R., Alexander, H. & Alexander, S. Sep-2006 In : Trends in Molecular Medicine. 12, 9, p. 415-424, 10 p.

Research output: Contribution to journal › Scientific review

QM/MM models of the O-2-evolving complex of photosystem II

Sproviero, E. M., Jose, A. G., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. 11-Jul-2006 In : Journal of chemical theory and computation. 2, 4, p. 1119-1134, 16 p.

Research output: Contribution to journal › Scientific review

The intestinal life cycle of Bacillus subtilis and close relatives

Tam, N. K. M., Uyen, N. Q., Hong, H. A., Duc, L. H., Hoa, T. T., Serra, C. R., Henriques, A. O. & Cutting, S. M. 1-Apr-2006 In : Journal of Bacteriology. 188, 7, p. 2692-700, 9 p.

Research output: Contribution to journal › Article

Characterization of synthetic oxomanganese complexes and the inorganic core of the O-2-evolving complex in photosystem - II: Evaluation of the DFT/B3LYP level of theory

Sproviero, E. M., Gascon, J. A., McEvoy, J. P., Brudvig, G. W. & Batista, V. S. Apr-2006 In : Journal of inorganic biochemistry. 100, 4, p. 786-800, 15 p.

Research output: Contribution to journal › Scientific review

Carotenoids present in halotolerant Bacillus spore formers

Duc, L. H., Fraser, P. D., Tam, N. K. M. & Cutting, S. M. 1-Feb-2006 In : FEMS Microbiology Letters. 255, 2, p. 215-24, 10 p.

Research output: Contribution to journal › Article

A novel mode of tangential migration of cortical projection neurons

Britanova, O., Alifragis, P., Junek, S., Jones, K., Gruss, P. & Tarabykin, V. 2006 In : Dev Biol. 298, 1, p. 299-311, 13 p.

Research output: Contribution to journal › Article

Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion

Fabes, J., Anderson, P., Yáñez-Muñoz, R. J., Thrasher, A., Brennan, C. & Bolsover, S. 2006 In : European Journal of Neuroscience. 23, 7, p. 1721-30, 10 p.

Research output: Contribution to journal › Article

African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages

Redrejo-Rodriguez, M., Garcia-Escudero, R., Yáñez-Muñoz, R. J., Salas, M. L. & Salas, J. 2006 In : J Virol. 80, 10, p. 4847-57, 11 p.

Research output: Contribution to journal › Article

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., Murdoch, J., Warchol, M. E., Wenthold, R. J. & Kelley, M. W. 2006 In : The Journal of Neuroscience. 26, 19, p. 5265-5275, 11 p.

Research output: Contribution to journal › Article

Conserved prefusion protein assembly in regulated exocytosis

Rickman, C., Jiménez, J. L., Graham, M. E., Archer, D. A., Soloviev, M., Burgoyne, R. D. & Davletov, B. 2006 In : Molecular biology of the cell. 17, 1, p. 283-94, 12 p.

Research output: Contribution to journal › Article

Cytokines and Proteoglycans: an introductory overview

Mulloy, B. & Rider, C. C. 2006 In : Biochemical Society Transactions. 34, p. 409-413, 5 p.

Research output: Contribution to journal › Article

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

Harris, J. D., Graham, I. R., Amalfitano, A., Owen, J. S. & Dickson, G. 2006 In : GENE THERAPY AND MOLECULAR BIOLOGY. 10A, p. 17-29, 13 p.

Research output: Contribution to journal › Article

Effective gene therapy with nonintegrating lentiviral vectors

Yáñez-Muñoz, R. J., Balaggan, K. S., MacNeil, A., Howe, S. J., Schmidt, M., Smith, A. J., Buch, P., MacLaren, R. E., Anderson, P. N., Barker, S., Duran, Y., Bartholomae, C., von Kalle, C., Heckenlively, J. R., Kinnon, C., Ali, R. R. & Thrasher, A. J. 2006 In : Nature Medicine. 12, p. 348-353

Research output: Contribution to journal › Article

Enhanced immunisation and expression strategies using bacterial spores as heat-stable vaccine delivery vehicles

Uyen, N. Q., Hong, H. A. & Cutting, S. M. 2006 In : Vaccine. 25, 2, p. 356-65, 10 p.

Research output: Contribution to journal › Article

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquino xalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission

Frizelle, P. A., Chen, P. E. & Wyllie, D. J. 2006 In : Molecular Pharmacology. 70, 3, p. 1022-32, 11 p.

Research output: Contribution to journal › Article

Evidence from bioinformatics, expression and inhibition studies of phosphoinositide-3 kinase signalling in Giardia intestinalis

Cox, S. S. E., van der Giezen, M., Tarr, S. J., Crompton, M. R. & Tovar, J. 2006 In : BMC Microbiology. 6, p. 45

Research output: Contribution to journal › Article

Gene therapy progress and prospects: Duchenne muscular dystrophy

Foster, K., Foster, H. & Dickson, J. G. 2006 In : Human Gene Therapy. 13, 24, p. 1677-85, 9 p.

Research output: Contribution to journal › Article

Heparin/Heparan Sulphate Binding in the TGF-? Cytokine Superfamily

Rider, C. C. 2006 In : Biochemical Society Transactions. 34, p. 458-460, 3 p.

Research output: Contribution to journal › Article

Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen

Duc, L. H., Hong, H. A., Atkins, H. S., Flick-Smith, H. C., Durrani, Z., Rijpkema, S., Titball, R. W. & Cutting, S. M. 2006 In : Vaccine. 25, 2, p. 346-55, 10 p.

Research output: Contribution to journal › Article

Pax7 and myogenic progression in skeletal muscle satellite cells

Zammit, P. S., Relaix, F., Nagata, Y., Ruiz, A. P., Collins, C. A., Partridge, T. A. & Beauchamp, J. R. 2006 In : Journal of Cell Science. 119, Pt 9, p. 1824-32, 9 p.

Research output: Contribution to journal › Article

Peptidomics: bridging the gap between proteome and metabolome

Soloviev, M. & Finch, P. 2006 In : Proteomics. 6, 3, p. 744-7, 4 p.

Research output: Contribution to journal › Article

Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors

Chen, P. E. & Wyllie, D. J. 2006 In : British Journal of Pharmacology. 147, 8, p. 839-53, 15 p.

Research output: Contribution to journal › Article

Polarization and orientation of retinal ganglion cells in vivo

Zolessi, F. R., Poggi, L., Wilkinson, C. J., Chien, C. B. & Harris, W. A. 2006 In : Neural development. 1, 2, p. 2-23, 22 p.

Research output: Contribution to journal › Article

Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

Wyllie, D. J., Johnston, A. R., Lipscombe, D. & Chen, P. E. 2006 In : Journal of Physiology. 574, Pt 2, p. 477-89, 13 p.

Research output: Contribution to journal › Article

Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice

Ito, K., Kimura, S., Ozasa, S., Matsukura, M., Ikezawa, M., Yoshioka, K., Ueno, H., Suzuki, M., Araki, K., Yamamura, K., Miwa, T., Dickson, G., Thomas, G. D. & Miike, T. 2006 In : Human Molecular Genetics. 15, 14, p. 2266-75, 10 p.

Research output: Contribution to journal › Article

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

Wilkinson, C. J. & 41 others Sayer, J. A., Otto, E. A., O'Toole, J. F., Nurnberg, G., Kennedy, M. A., Becker, C., Hennies, H. C., Helou, J., Attanasio, M., Fausett, B. V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R. G., Allen, S. J., Nigg, E. A., Shou, C., Lillo, C., Williams, D. S., Hoppe, B., Kemper, M. J., Neuhaus, T., Parisi, M. A., Glass, I. A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M. R. & Hildebrandt, F. 2006 In : Nature Genetics. 38, 6, p. 674-81, 8 p.

Research output: Contribution to journal › Article

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells

Gillingwater, T. H., Wishart, T. M., Chen, P. E., Haley, J. E., Robertson, K., MacDonald, S. H., Middleton, S., Wawrowski, K., Shipston, M. J., Melmed, S., Wyllie, D. J., Skehel, P. A., Coleman, M. P. & Ribchester, R. R. 2006 In : Human Molecular Genetics. 15, 4, p. 625-35, 11 p.

Research output: Contribution to journal › Article

The mechanism of photosynthetic water splitting

McEvoy, J. P., Gascon, J. A., Batista, V. S. & Brudvig, G. W. Dec-2005 In : Photochemical and Photobiological Sciences. 4, 12, p. 940-949, 10 p.

Research output: Contribution to journal › Scientific review

Cases of emesis associated with bacterial contamination of an infant breakfast cereal product

Duc, L. H., Dong, T. C., Logan, N. A., Sutherland, A. D., Taylor, J. & Cutting, S. M. 15-Jul-2005 In : International journal of food microbiology. 102, 2, p. 245-51, 7 p.

Research output: Contribution to journal › Article

Pharmacogenetics in model systems: Defining a common mechanism of action for mood stabilisers

Williams, R. S. B. Jul-2005 In : PROGRESS IN NEURO-PSYCHOPHARMACOLOGY. 29, 6, p. 1029-1037, 9 p.

Research output: Contribution to journal › Scientific review

GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid

Ryves, W. J., Dalton, E. C., Harwood, A. J. & Williams, R. S. B. Jun-2005 In : Bipolar Disorders. 7, 3, p. 260-265, 6 p.

Research output: Contribution to journal › Article

Direct electrochemistry of blue copper proteins at boron-doped diamond electrodes

McEvoy, J. P. & Foord, J. S. 5-May-2005 In : Electrochimica acta. 50, 14, p. 2933-2941, 9 p.

Research output: Contribution to journal › Article

Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure

Eickholt, B. J., Towers, G. J., Ryves, W. J., Eikel, D., Adley, K., Ylinen, L. M. J., Chadborn, N. H., Harwood, A. J., Nau, H. & Williams, R. S. B. May-2005 In : Molecular Pharmacology. 67, 5, p. 1426-1433, 8 p.

Research output: Contribution to journal › Article

From fundamental studies of sporulation to applied spore research

Barák, I., Ricca, E. & Cutting, S. M. 1-Jan-2005 In : Molecular microbiology. 55, 2, p. 330-8, 9 p.

Research output: Contribution to journal › Article

A novel ADP/ATP transporter in the mitosome of the microaerophilic human parasite Entamoeba histolytica

Chan, K. W., Slotboom, D-J., Cox, S., Embley, T. M., Fabre, O., van der Giezen, M., Harding, M., Horner, D. S., Kunji, E. R. S., León-Avila, G. & Tovar, J. 2005 In : Current Biology . 15, 8, p. 737-42, 6 p.

Research output: Contribution to journal › Article

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice

Tagalakis, A. D., Diakonov, I. A., Graham, I. R., Heald, K. A., Harris, J. D., Mulcahy, J. V., Dickson, G. & Owen, J. S. 2005 In : BBA - Gene Structure and Expression . 1686 3, p. 190-9, 10 p.

Research output: Contribution to journal › Article

Characterization of chaperonin 10 (Cpn10) from the intestinal human pathogen Entamoeba histolytica

van der Giezen, M., León-Avila, G. & Tovar, J. 2005 In : Microbiology (Reading, England). 151, Pt 9, p. 3107-15, 9 p.

Research output: Contribution to journal › Article

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts)

Tagalakis, A. D., Dickson, J. G., Owen, J. S. & Simons, J. P. 2005 In : Journal of molecular neuroscience : MN. 25, 1, p. 95-103, 9 p.

Research output: Contribution to journal › Article

Degenerate mitochondria

van der Giezen, M. & Tovar, J. 2005 In : EMBO Reports. 6, 6, p. 525-30, 6 p.

Research output: Contribution to journal › Article

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

Murdoch, J. N. & 23 others Ross, A. J., May-Simera, H., Eichers, E. R., Kai, M., Hill, J., Jagger, D. J., Leitch, C. C., Chapple, J. P., Munro, P. M., Fisher, S., Tan, P. L., Phillips, H. M., Leroux, M. R., Henderson, D. J., Copp, A. J., Eliot, M. M., Lupski, J. R., Kemp, D. T., Dollfus, H., Tada, M., Katsanis, N., Forge, A. & Beales, P. L. 2005 In : Nature Genetics. 37, 10, p. 1135-1140, 6 p.

Research output: Contribution to journal › Article

Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: implications for mucosal vaccines

Rozis, G., de Silva, S., Benlahrech, A., Papagatsias, T., Harris, J., Gotch, F., Dickson, G. & Patterson, S. 2005 In : European Journal of Immunology. 35, 9, p. 2617-26, 10 p.

Research output: Contribution to journal › Article

Mitochondrion-derived organelles in protists and fungi

van der Giezen, M., Tovar, J. & Clark, C. G. 2005 In : International review of cytology. 244, p. 175-225, 51 p.

Research output: Contribution to journal › Article

Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1

Ekonomou, A., Kazanis, I., Malas, S., Wood, H., Alifragis, P., Denaxa, M., Karagogeos, D., Constanti, A., Lovell-Badge, R. & Episkopou, V. 2005 In : PLoS Biology. 3, 6, p. e186

Research output: Contribution to journal › Article

Peptidomics, current status

Soloviev, M. & Finch, P. 2005 In : Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 815, 1-2, p. 11-24, 14 p.

Research output: Contribution to journal › Article

Protein import, replication, and inheritance of a vestigial mitochondrion

Regoes, A., Zourmpanou, D., León-Avila, G., van der Giezen, M., Tovar, J. & Hehl, A. B. 2005 In : Journal of Biological Chemistry. 280, 34, p. 30557-63, 7 p.

Research output: Contribution to journal › Article

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

Bahe, S., Stierhof, Y-D., Wilkinson, C. J., Leiss, F. & Nigg, E. A. 2005 In : J Cell Biol. 171, 1, p. 27-33, 7 p.

Research output: Contribution to journal › Article

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

Chen, P. E., Geballe, M. T., Stansfeld, P. J., Johnston, A. R., Yuan, H., Jacob, A. L., Snyder, J. P., Traynelis, S. F. & Wyllie, D. J. 2005 In : Molecular Pharmacology. 67, 5, p. 1470-84, 15 p.

Research output: Contribution to journal › Article

The Polo kinase Plk4 functions in centriole duplication

Habedanck, R., Stierhof, Y-D., Wilkinson, C. J. & Nigg, E. A. 2005 In : Nature Cell Biology. 7, 11, p. 1140-6, 7 p.

Research output: Contribution to journal › Article

Vangl2 Acts via RhoA Signaling to Regulate Polarized Cell Movements During Development of the Proximal Outflow Tract

Phillips, H. M., Murdoch, J. N., Chaudhry, B., Copp, A. J. & Henderson, D. J. 2005 In : Circulation Research. 96, p. 292-299

Research output: Contribution to journal › Article

Mood stabilizers and the cell biology of neuronal growth cones

Eickholt, B. J., Williams, R. S. B. & Harwood, A. J. Dec-2004 In : Clinical Neuroscience Research. 4, 3-4, p. 189-199, 11 p.

Research output: Contribution to journal › Scientific review

Prolyl oligopeptidase and bipolar disorder

Williams, R. S. B. Dec-2004 In : Clinical Neuroscience Research. 4, 3-4, p. 233-242, 10 p.

Research output: Contribution to journal › Scientific review

A molecular cell biology of lithium

Williams, R., Ryves, W. J., Dalton, E. C., Eickholt, B., Shaltiel, G., Agam, G. & Harwood, A. J. Nov-2004 In : Biochemical Society Transactions. 32, p. 799-802, 4 p.

Research output: Contribution to journal › Article

Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD)

Athanasopoulos, T., Graham, I. R., Foster, H. & Dickson, G. Oct-2004 In : Human Gene Therapy. 11 Suppl 1, p. S109-S121, 13 p.

Research output: Contribution to journal › Article

Phage display technologies

Soloviev, M. 1-Jun-2004 In : Current Drug Discovery. JUNE, p. 25-28, 4 p.

Research output: Contribution to journal › Article

Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins

Ferrer, A., Foster, H., Wells, K. E., Dickson, G. & Wells, D. J. Jun-2004 In : Human Gene Therapy. 11, 11, p. 884-893, 10 p.

Research output: Contribution to journal › Article

Intracellular fate and immunogenicity of B. subtilis spores

Duc, L. H., Hong, H. A., Uyen, N. Q. & Cutting, S. M. 7-May-2004 In : Vaccine. 22, 15-16, p. 1873-85, 13 p.

Research output: Contribution to journal › Article

DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT

Dong, T. C., Cutting, S. M. & Lewis, R. J. 15-Apr-2004 In : FEMS Microbiology Letters. 233, 2, p. 247-56, 10 p.

Research output: Contribution to journal › Article

Characterization of Bacillus probiotics available for human use

Duc, L. H., Hong, H. A., Barbosa, T. M., Henriques, A. O. & Cutting, S. M. 1-Apr-2004 In : Applied and environmental microbiology. 70, 4, p. 2161-71, 11 p.

Research output: Contribution to journal › Article

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients

Breen, G., Harwood, A. J., Gregory, K., Sinclair, M., Collier, D., St Clair, D. & Williams, R. S. B. Apr-2004 In : Bipolar Disorders. 6, 2, p. 156-161, 6 p.

Research output: Contribution to journal › Article

Display of heterologous antigens on the Bacillus subtilis spore coat using CotC as a fusion partner

Mauriello, E. M. F., Duc, L. H., Isticato, R., Cangiano, G., Hong, H. A., De Felice, M., Ricca, E. & Cutting, S. M. 12-Mar-2004 In : Vaccine. 22, 9-10, p. 1177-87, 11 p.

Research output: Contribution to journal › Article

An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutants

Keim, M., Williams, R. S. B. & Harwood, A. J. Mar-2004 In : MOLECULAR BIOTECHNOLOGY. 26, 3, p. 221-224, 4 p.

Research output: Contribution to journal › Article

Proline peptidase activities decreased in bipolar disorder not schizophrenia

Breen, G., Harwood, A. J., Gregory, K., Sinclair, M., Collier, D., St Clair, D. & Williams, R. S. B. Mar-2004 In : EUROPEAN NEUROPSYCHOPHARMACOLOGY. 14, p. S50-S51, 2 p.

Research output: Contribution to journal › Article

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, J. 2004 In : Nature Cell Biology. 6, 9, p. 884-91, 8 p.

Research output: Contribution to journal › Article

Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart

Suzuki, K., Murtuza, B., Beauchamp, J. R., Smolenski, R. T., Varela-Carver, A., Fukushima, S., Coppen, S. R., Partridge, T. A. & Yacoub, M. H. 2004 In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 10, p. 1153-5, 3 p.

Research output: Contribution to journal › Article

Glutamate receptor gating

Erreger, K., Chen, P. E., Wyllie, D. J. & Traynelis, S. F. 2004 In : Crit Rev Neurobiol. 16, 3, p. 187-224, 38 p.

Research output: Contribution to journal › Article

Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs

Golding, J. P., Tsoni, S., Dixon, M., Yee, K. T., Partridge, T. A., Beauchamp, J. R., Gassmann, M. & Zammit, P. S. 2004 In : Gene expression patterns : GEP. 5, 1, p. 3-9, 7 p.

Research output: Contribution to journal › Article

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

Chen, P. E., Johnston, A. R., Mok, M. H., Schoepfer, R. & Wyllie, D. J. 2004 In : Journal of Physiology. 558, Pt 1, p. 45-58, 14 p.

Research output: Contribution to journal › Article

Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype

Alifragis, P., Liapi, A. & Parnavelas, J. G. 2004 In : The Journal of Neuroscience. 24, 24, p. 5643-8, 6 p.

Research output: Contribution to journal › Article

Mitosomes of Entamoeba histolytica are abundant mitochondrion-related remnant organelles that lack a detectable organellar genome

León-Avila, G. & Tovar, J. 2004 In : Microbiology (Reading, England). 150, Pt 5, p. 1245-50, 6 p.

Research output: Contribution to journal › Article

Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin

Golding, J. P., Partridge, T. A., Beauchamp, J. R., King, T., Brown, N. A., Gassmann, M. & Zammit, P. S. 2004 In : Developmental dynamics : an official publication of the American Association of Anatomists. 231, 4, p. 795-800, 6 p.

Research output: Contribution to journal › Article

Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?

Zammit, P. S., Golding, J. P., Nagata, Y., Hudon, V., Partridge, T. A. & Beauchamp, J. R. 2004 In : The Journal of cell biology. 166, 3, p. 347-57, 11 p.

Research output: Contribution to journal › Article

Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements

Zammit, P. S., Carvajal, J. J., Golding, J. P., Morgan, J. E., Summerbell, D., Zolnerciks, J., Partridge, T. A., Rigby, P. W. J. & Beauchamp, J. R. 2004 In : Developmental Biology. 273, 2, p. 454-65, 12 p.

Research output: Contribution to journal › Article

Pax7 distribution in human skeletal muscle biopsies and myogenic tissue cultures

Reimann, J., Brimah, K., Schröder, R., Wernig, A., Beauchamp, J. R. & Partridge, T. A. 2004 In : Cell and tissue research. 315, 2, p. 233-42, 10 p.

Research output: Contribution to journal › Article

Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy

Dickson, G. & 24 others Romero, N. B., Braun, S., Benveniste, O., Leturcq, F., Hogrel, J-Y., Morris, G. E., Barois, A., Eymard, B., Payan, C., Ortega, V., Boch, A-L., Lejean, L., Thioudellet, C., Mourot, B., Escot, C., Choquel, A., Recan, D., Kaplan, J-C., Klatzmann, D., Molinier-Frenckel, V., Guillet, J-G., Squiban, P., Herson, S. & Fardeau, M. 2004 In : Human Gene Therapy. 15, 11, p. 1065-76, 12 p.

Research output: Contribution to journal › Article

Quantitative protein profiling using antibody arrays

Barry, R. & Soloviev, M. 2004 In : Proteomics. 4, 12, p. 3717-26, 10 p.

Research output: Contribution to journal › Article

Role of interleukin-1beta in acute inflammation and graft death after cell transplantation to the heart

Suzuki, K., Murtuza, B., Beauchamp, J. R., Brand, N. J., Barton, P. J. R., Varela-Carver, A., Fukushima, S., Coppen, S. R., Partridge, T. A. & Yacoub, M. H. 2004 In : Circulation. 110, 11 Suppl 1, p. II219-24

Research output: Contribution to journal › Article

Structure-based mechanism of photosynthetic water oxidation

McEvoy, J. P. & Brudvig, G. W. 2004 In : Physical Chemistry Chemical Physics. 6, 20, p. 4754-4763, 10 p.

Research output: Contribution to journal › Scientific review

The iron-sulfur cluster assembly genes iscS and iscU of Entamoeba histolytica were acquired by horizontal gene transfer

van der Giezen, M., Cox, S. & Tovar, J. 2004 In : BMC Evolutionary Biology. 4, p. 7

Research output: Contribution to journal › Article

The PDZ domain of the SpoIVB transmembrane signaling protein enables cis-trans interactions involving multiple partners leading to the activation of the pro-sigmaK processing complex in Bacillus subtilis

Dong, T. C. & Cutting, S. M. 2004 In : Journal of Biological Chemistry. 279, 42, p. 43468-78, 11 p.

Research output: Contribution to journal › Article

The use of bacterial spore formers as probiotics

Hong, H. A., Duc, L. H. & Cutting, S. M. 2004 In : FEMS Microbiology Reviews. 29, 4, p. 813-35, 23 p.

Research output: Contribution to journal › Article

Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays

Graham, I. R., Hill, V. J., Manoharan, M., Inamati, G. B. & Dickson, G. 2004 In : Journal of Gene Medicine. 6, 10, p. 1149-58, 10 p.

Research output: Contribution to journal › Article

Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium

Murtuza, B., Suzuki, K., Bou-Gharios, G., Beauchamp, J. R., Smolenski, R. T., Partridge, T. A. & Yacoub, M. H. 2004 In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4216-21, 6 p.

Research output: Contribution to journal › Article

Bacterial spores as heat stable vaccine vehicles

Duc, L. H. & Cutting, S. M. 1-Dec-2003 In : Expert Opinion on Biological Therapy. 3, 8, p. 1263-70, 8 p.

Research output: Contribution to journal › Article

Germination of the spore in the gastrointestinal tract provides a novel route for heterologous antigen delivery

Duc, L. H., Hong, H. A. & Cutting, S. M. 1-Oct-2003 In : Vaccine. 21, 27-30, p. 4215-24, 10 p.

Research output: Contribution to journal › Article

SpoIVB-mediated cleavage of SpoIVFA could provide the intercellular signal to activate processing of Pro-sigmaK in Bacillus subtilis

Dong, T. C. & Cutting, S. M. 1-Sep-2003 In : Molecular microbiology. 49, 5, p. 1425-34, 10 p.

Research output: Contribution to journal › Article

Bacterial spores as vaccine vehicles

Duc, L. H., Hong, H. A., Fairweather, N., Ricca, E. & Cutting, S. M. 1-May-2003 In : Infection and immunity. 71, 5, p. 2810-8, 9 p.

Research output: Contribution to journal › Article

Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling

Rudhard, Y., Kneussel, M., Nassar, M. A., Rast, G. F., Annala, A. J., Chen, P. E., Tigaret, C. M., Dean, I., Roes, J., Gibb, A. J., Hunt, S. P. & Schoepfer, R. 2003 In : The Journal of Neuroscience. 23, 6, p. 2323-32, 10 p.

Research output: Contribution to journal › Article

Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

Oliynyk, M., Stark, C. B., Bhatt, A., Jones, M. A., Hughes-Thomas, Z. A., Wilkinson, C., Oliynyk, Z., Demydchuk, Y., Staunton, J. & Leadlay, P. F. 2003 In : Mol Microbiol. 49, 5, p. 1179-90, 12 p.

Research output: Contribution to journal › Article

Combinatorial peptidomics: a generic approach for protein expression profiling

Soloviev, M., Barry, R., Scrivener, E. & Terrett, J. 2003 In : Journal of Nanobiotechnology. 1, 1, p. 4

Research output: Contribution to journal › Article

Competitive assay formats for high-throughput affinity arrays

Barry, R., Diggle, T., Terrett, J. & Soloviev, M. 2003 In : Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 8, 3, p. 257-63, 7 p.

Research output: Contribution to journal › Article

Dishevelled: linking convergent extension with neural tube closure

Copp, A. J., Greene, N. D. E. & Murdoch, J. N. 2003 In : Trends in Neuroscience. 26, p. 453-455, 3 p.

Research output: Contribution to journal › Article

Disruption of scribble ( Scrb1 ) causes severe neural tube defects in the circletail mouse

Murdoch, J. N., Henderson, D. J., Doudney, K., Gaston-Massuet, C., Phillips, H. M., Paternotte, C., Arkell, R., Stanier, P. & Copp, A. J. 2003 In : Human Molecular Genetics. 12, p. 87-98, 12 p.

Research output: Contribution to journal › Article

Emerging Applications of Bacterial Spores in Nanobiotechnology

Ricca, E. & Cutting, S. M. 2003 In : Journal of Nanobiotechnology. 1, 1, p. 6

Research output: Contribution to journal › Article

Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts)

Manzano, A., Mohri, Z., Sperber, G., Ogris, M., Graham, I., Dickson, G. & Owen, J. S. 2003 In : Journal of Gene Medicine. 5, 9, p. 795-802, 8 p.

Research output: Contribution to journal › Article

Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia

Murdoch, J. N., Doudney, K., Gerrelli, D., Wortham, N., Paternotte, C., Stanier, P. & Copp, A. J. 2003 In : Molecular and Cellular Neuroscience. 22, 1, p. 62-74, 13 p.

Research output: Contribution to journal › Article

Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation

Tovar, J., León-Avila, G., Sánchez, L. B., Sutak, R., Tachezy, J., van der Giezen, M., Hernández, M., Müller, M. & Lucocq, J. M. 2003 In : Nature. 426, 6963, p. 172-6, 5 p.

Research output: Contribution to journal › Article

Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.

Curtin, J., Quint, E., Tsipouri, V., Arkell, R., Cattanach, B., Copp, A., Henderson, D., Spurr, N., Stanier, P., Fisher, E., Nolan, P., Steel, K., Brown, S., Gray, I. & Murdoch, J. 2003 In : Current Biology. 13, p. 1-20

Research output: Contribution to journal › Article

Neuronal migration in the developing cerebral cortex: observations based on real-time imaging

Nadarajah, B., Alifragis, P., Wong, R. O. & Parnavelas, J. G. 2003 In : Cerebral Cortex. 13, 6, p. 607-11, 5 p.

Research output: Contribution to journal › Article

Novel tools for production and purification of recombinant adeno-associated viral vectors

Harris, J. D., Beattie, S. G. & Dickson, J. G. 2003 In : Methods in molecular medicine. 76, p. 255-67, 13 p.

Research output: Contribution to journal › Article

Peptidomics: A new approach to affinity protein microarrays

Scrivener, E., Barry, R., Platt, A., Calvert, R., Masih, G., Hextall, P., Soloviev, M. & Terrett, J. 2003 In : Proteomics. 3, 2, p. 122-8, 7 p.

Research output: Contribution to journal › Article

Proteomic characterization of the human centrosome by protein correlation profiling

Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A. & Mann, M. 2003 In : Nature. 426, 6966, p. 570-4, 5 p.

Research output: Contribution to journal › Article

Qu'est-ce qu'une cellule musculaire satellite?

Mouly, V. & Beauchamp, J. 2003 In : Médecine sciences : M/S. 19, 6-7, p. 696

Research output: Contribution to journal › Article

Restricted expression of Slap-1 in the rodent cerebral cortex

Alifragis, P., Molnar, Z. & Parnavelas, J. G. 2003 In : Gene Expr Patterns. 3, 4, p. 437-40, 4 p.

Research output: Contribution to journal › Article

Self-assembly of proteins and their nucleic acids

Fletcher, G., Mason, S., Terrett, J. & Soloviev, M. 2003 In : Journal of Nanobiotechnology. 1, 1, p. 1

Research output: Contribution to journal › Article

Tangential migration of cells from the basal to the dorsal telencephalic regions in the chick

Tuorto, F., Alifragis, P., Failla, V., Parnavelas, J. G. & Gulisano, M. 2003 In : European Journal of Neuroscience. 18, 12, p. 3388-93, 6 p.

Research output: Contribution to journal › Article

The Binding of Human Glial Cell-Line Derived Neurotrophic Factor (GDNF) to Heparin and Heparan Sulphate: Importance of 2-O-Sulphate Groups and Effects on its Interaction with its Receptor GFR?1

Rickard, S. M., Mummery, R. S., Mulloy, B. & Rider, C. C. 2003 In : Glycobiology. 13, p. 419-426, 8 p.

Research output: Contribution to journal › Article

The genetic basis of mammalian neurulation

Copp, A. J., Greene, N. D. & Murdoch, J. N. 2003 In : Nature Reviews Genetics. 4, 10, p. 784-793, 10 p.

Research output: Contribution to journal › Article

The Interaction between Glial Cell-line Derived Neurotrophic Factor (GDNF) and 2-O-Sulphated Heparin-Related Glycosaminoglycans

Rider, C. C. 2003 In : Biochemical Society Transactions. 31, p. 337-339, 3 p.

Research output: Contribution to journal › Article

Two modes of recruitment of E(spl) repressors onto target genes

Giagtzoglou, N., Alifragis, P., Koumbanakis, K. A. & Delidakis, C. 2003 In : Social Development. 130, 2, p. 259-70, 12 p.

Research output: Contribution to journal › Article

Recombinant micro-genes and dystrophin viral vectors

Dickson, G., Roberts, M. L., Wells, D. J. & Fabb, S. A. Oct-2002 In : Neuromuscular Disorders. 12, p. S40-S44, 5 p.

Research output: Contribution to journal › Article

Screening for antisense modulation of dystrophin pre-mRNA splicing

Dickson, G., Hill, V. & Graham, I. R. Oct-2002 In : Neuromuscular Disorders. 12, p. S67-S70, 4 p.

Research output: Contribution to journal › Article

Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium

Coates, J. C., Grimson, M. J., Williams, R. S. B., Bergman, W., Blanton, R. L. & Harwood, A. J. Aug-2002 In : MECHANISMS OF DEVELOPMENT. 116, 1-2, p. 117-127, 11 p.

Research output: Contribution to journal › Article

A common mechanism of action for three mood-stabilizing drugs

Williams, R. S. B., Cheng, L. L., Mudge, A. W. & Harwood, A. J. 16-May-2002 In : Nature. 417, 6886, p. 292-295, 4 p.

Research output: Contribution to journal › Article

Bacillus probiotics: spore germination in the gastrointestinal tract

Casula, G. & Cutting, S. M. 1-May-2002 In : Applied and environmental microbiology. 68, 5, p. 2344-52, 9 p.

Research output: Contribution to journal › Article

Insights into gated electron-transfer kinetics at the electrode-protein interface: A square wave voltammetry study of the blue copper protein azurin

Jeuken, L. J. C., McEvoy, J. P. & Armstrong, F. A. 7-Mar-2002 In : Journal of Physical Chemistry B. 106, 9, p. 2304-2313, 10 p.

Research output: Contribution to journal › Article

Crystal structures of ferredoxin variants exhibiting large changes in [Fe-S] reduction potential

Chen, K. S., Bonagura, C. A., Tilley, G. J., McEvoy, J. P., Jung, Y. S., Armstrong, F. A., Stout, C. D. & Burgess, B. K. Mar-2002 In : Nature structural biology. 9, 3, p. 188-192, 5 p.

Research output: Contribution to journal › Article

Identification of the Axin and Frat binding region of glycogen synthase kinase-3

Fraser, E., Young, N., Dajani, R., Franca-Koh, J., Ryves, J., Williams, R. S. B., Yeo, M., Webster, M. T., Richardson, C., Smalley, M. J., Pearl, L. H., Harwood, A. & Dale, T. C. 18-Jan-2002 In : Journal of Biological Chemistry. 277, 3, p. 2176-2185, 10 p.

Research output: Contribution to journal › Article

The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidases

Hoa, N. T., Brannigan, J. A. & Cutting, S. M. 1-Jan-2002 In : Journal of Bacteriology. 184, 1, p. 191-9, 9 p.

Research output: Contribution to journal › Article

Inhibition of atherosclerosis in apolipoprotein-E-deficient mice following muscle transduction with adeno-associated virus vectors encoding human apolipoprotein-E

Harris, J. D., Schepelmann, S., Athanasopoulos, T., Graham, I. R., Stannard, A. K., Mohri, Z., Hill, V., Hassall, D. G., Owen, J. S. & Dickson, G. Jan-2002 In : Human Gene Therapy. 9, 1, p. 21-29, 9 p.

Research output: Contribution to journal › Article

A chromosomal position effect on gene targeting in human cells

Yáñez, R. J. & Porter, A. C. G. 2002 In : Nucleic Acids Research. 30, p. 4892-4901, 10 p.

Research output: Contribution to journal › Article

A novel method of labeling and characterizing migrating neurons in the developing central nervous system

Alifragis, P., Parnavelas, J. G. & Nadarajah, B. 2002 In : Exp Neurol. 174, 2, p. 259-65, 7 p.

Research output: Contribution to journal › Article

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE

Harris, J. D., Graham, I. R., Schepelmann, S., Stannard, A. K., Roberts, M. L., Hodges, B. L., Hill, V., Amalfitano, A., Hassall, D. G., Owen, J. S. & Dickson, G. 2002 In : Human Molecular Genetics. 11, 1, p. 43-58, 16 p.

Research output: Contribution to journal › Article

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

Fabb, S. A., Wells, D. J., Serpente, P. & Dickson, G. 2002 In : Human Molecular Genetics. 11, 7, p. 733-41, 9 p.

Research output: Contribution to journal › Article

Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system

Doudney, K., Murdoch, J. N., Braybrook, C., Paternotte, C., Bentley, L., Copp, A. J. & Stanier, P. 2002 In : Genomics. 79, 5, p. 663-670, 8 p.

Research output: Contribution to journal › Article

Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line

Yáñez, R. J. & Porter, A. C. G. 2002 In : Nucleic Acids Research. 30, 3, p. 740-8, 9 p.

Research output: Contribution to journal › Article

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

Long, P. F., Wilkinson, C. J., Bisang, C. P., Cortés, J., Dunster, N., Oliynyk, M., McCormick, E., McArthur, H., Mendez, C., Salas, J. A., Staunton, J. & Leadlay, P. F. 2002 In : Mol Microbiol. 43, 5, p. 1215-25, 11 p.

Research output: Contribution to journal › Article

Gene repair and mutagenesis mediated by chimeric RNA-DNA oligonucleotides: chimeraplasty for gene therapy and conversion of single nucleotide polymorphisms (SNPs)

Graham, I. R. & Dickson, G. 2002 In : BBA - Gene Structure and Expression . 1587, 1, p. 1-6, 6 p.

Research output: Contribution to journal › Article

Increasing the efficiency of heterologous promoters in actinomycetes

Wilkinson, C. J., Hughes-Thomas, Z. A., Martin, C. J., Böhm, I., Mironenko, T., Deacon, M., Wheatcroft, M., Wirtz, G., Staunton, J. & Leadlay, P. F. 2002 In : J Mol Microbiol Biotechnol. 4, 4, p. 417-26, 10 p.

Research output: Contribution to journal › Article

Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers

Zammit, P. S., Heslop, L., Hudon, V., Rosenblatt, J. D., Tajbakhsh, S., Buckingham, M. E., Beauchamp, J. R. & Partridge, T. A. 2002 In : Experimental cell research. 281, 1, p. 39-49, 11 p.

Research output: Contribution to journal › Article

Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgene

Sakamoto, M., Yuasa, K., Yoshimura, M., Yokota, T., Ikemoto, T., Suzuki, M., Dickson, G., Miyagoe-Suzuki, Y. & Takeda, S. 2002 In : BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 293, 4, p. 1265-72, 8 p.

Research output: Contribution to journal › Article

Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site

Morgan, J. E., Gross, J. G., Pagel, C. N., Beauchamp, J. R., Fassati, A., Thrasher, A. J., Di Santo, J. P., Fisher, I. B., Shiwen, X., Abraham, D. J. & Partridge, T. A. 2002 In : The Journal of cell biology. 157, 4, p. 693-702, 10 p.

Research output: Contribution to journal › Article

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

Thomas, I., Martin, C. J., Wilkinson, C. J., Staunton, J. & Leadlay, P. F. 2002 In : Chemistry and Biology. 9, 7, p. 781-7, 7 p.

Research output: Contribution to journal › Article

Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus

Chen, P. E., Specht, C. G., Morris, R. G. & Schoepfer, R. 2002 In : European Journal of Neuroscience. 16, 1, p. 154-8, 5 p.

Research output: Contribution to journal › Article

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle

Roberts, M. L., Wells, D. J., Graham, I. R., Fabb, S. A., Hill, V. J., Duisit, G., Yuasa, K., Takeda, S., Cosset, F-L. & Dickson, G. 2002 In : Human Molecular Genetics. 11, 15, p. 1719-30, 12 p.

Research output: Contribution to journal › Article

The future of Duchenne muscular dystrophy gene therapy: shrinking the dystrophin gene

Roberts, M. & Dickson, G. 2002 In : Current opinion in molecular therapeutics. 4, 4, p. 343-8, 6 p.

Research output: Contribution to journal › Article

The origin and migration of cortical neurons

Parnavelas, J. G., Alifragis, P. & Nadarajah, B. 2002 In : Prog Brain Res. 136, p. 73-80, 8 p.

Research output: Contribution to journal › Article

Ventricle-directed migration in the developing cerebral cortex

Nadarajah, B., Alifragis, P., Wong, R. O. & Parnavelas, J. G. 2002 In : Nature Neuroscience. 5, 3, p. 218-24, 7 p.

Research output: Contribution to journal › Article

The skeletal muscle satellite cell: stem cell or son of stem cell?

Zammit, P. S. & Beauchamp, J. R. Oct-2001 In : Differentiation. 68, 4-5, p. 193-204, 12 p.

Research output: Contribution to journal › Scientific review

The short RRKK motif from the metabotropic glutamate receptor 1B C-terminus confers endoglycosidase H sensitivity and endoplasmic reticulum retention to the mGluR1B unrelated transmembrane proteins

Soloviev, M. M., Chan, W. Y. & McIlhinney, R. A. J. Sep-2001 In : Journal of neurochemistry. 78, p. 185-185, 1 p.

Research output: Contribution to journal › Article

Oligonucleotide-based gene correction strategies: Applications to neuromuscular and cardiovascular diseases

Graham, I. R., Beattie, S. G., Hill, V. J. & Dickson, G. Aug-2001 In : CROATIAN MEDICAL JOURNAL. 42, 4, p. 467-472, 6 p.

Research output: Contribution to journal › Article

Gene repair validation

Graham, I. R., Manzano, A., Tagalakis, A. D., Mohri, Z., Sperber, G., Hill, V., Beattie, S., Schepelmann, S., Dickson, G. & Owen, J. S. Jun-2001 In : Nature biotechnology. 19, 6, p. 507-508, 2 p.

Research output: Contribution to journal › Letter