Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

Julian D. Harris, Ian R. Graham, Andrea Amalfitano, James S. Owen, George Dickson

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)17-29
Number of pages13
JournalGENE THERAPY AND MOLECULAR BIOLOGY
Volume10A
Publication statusPublished - 2006

Keywords

  • atherosclerosis
  • apolipoprotein E
  • gene therapy
  • adenovirus
  • MEDIATED GENE-TRANSFER
  • CYTOTOXIC T-LYMPHOCYTES
  • HEPATOCYTES IN-VIVO
  • KUPFFER CELLS LEADS
  • HEMOPHILIA-B DOGS
  • NF-KAPPA-B
  • IMMUNE-RESPONSES
  • RECOMBINANT ADENOVIRUS
  • MOUSE-LIVER
  • FACTOR-IX

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