Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

Victoria L. Patterson, Christine Damrau, Anju Paudyal, Benjamin Reeve, Daniel T. Grimes, Michelle E. Stewart, Debbie J. Williams, Pam Siggers, Andy Greenfield, Jennifer N. Murdoch

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1719-1739
Number of pages21
JournalHuman Molecular Genetics
Volume18
Issue number10
Early online date17 Feb 2009
DOIs
Publication statusPublished - 2009

Keywords

  • b01.050 a16.254 g05.355.315.310 y05.050 y08.010 b01.050.150.900.649.801.400.112.400.400 b01.050.150.900.649.865.635.505.500 b01.050.050.157.520.388 b01.050.050.199.520.520.388 b01.050.150.900.649.865.635.505.500.400.388 b01.050.050.157.520.420 b01.050.0 Body Patterning Down-Regulation Hedgehog Proteins Polydactyly Proteins Signal Transduction Spinal Dysraphism Animals Embryo, Mammalian Female Gene Expression Regulation, Developmental Humans Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mutation Neural Tube Spinal Cord genetics embryology metabolism embryology genetics genetics embryology metabolism embryology genetics

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